| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-09-30 |
| タイトル |
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|
タイトル |
Serotonergic neurotransmission in limbic regions may reflect therapeutic response of depressive patients: A PET study with 11C-WAY-100635 and 18F-MPPF. |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Soichiro Kitamura
Yasuyuki Kimura
Keisuke Takahata
Sho Moriguchi
Manabu Kubota
Hitoshi Shimada
Hironobu Endo
Yuhei Takado
Kazunori Kawamura
Ming-Rong Zhang
Tetsuya Suhara
Makoto Higuchi
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission has been implicated in the etiology of depression. Most antidepressants ameliorate depressive symptoms by increasing 5-HT at synaptic clefts but their effect on 5-HT receptors has yet to be clarified. 11C-WAY-100635 and 18F-MPPF are positron emission tomography (PET) radioligands for 5-HT1A receptors. While binding of both ligands reflects 5-HT1A receptor density, 18F-MPPF biding may also be affected by extracellular 5-HT concentrations. This dual-tracer PET study explored the neurochemical substrates underlying antidepressant effects in patients with depression. |
| 書誌情報 |
The international journal of neuropsychopharmacology
巻 26,
号 7,
p. 474-482,
発行日 2023-06
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| 出版者 |
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出版者 |
Oxford University Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1469-5111 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
37279545 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1093/ijnp/pyad026 |
