| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-14 |
| タイトル |
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タイトル |
Incorporation of a bromine atom into DNA-related molecules changes their electronic properties |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hirato Misaki
Yokoya Akinari
Baba Yuji
Seiji Mori
Fujii Kentaro
Shin-ichi Wada
Izumi Yudai
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
To understand the mechanism underlying the high radio-sensitisation of living cells possessing brominated genomic DNA, X-ray photoelectron spectroscopy (XPS) using synchrotron X-rays with energies of 2000 or 2500 eV was used to study brominated and nonbrominated nucleobases, nucleosides and nucleotides. The bromine atom significantly reduced the energy gap between the valence and conduction states, although the core level states were not greatly affected. This finding was supported by quantum chemical calculation for the nucleobases and nucleosides. Our findings strongly indicate that the energy gaps between the valence and conduction levels of the molecules are significantly reduced by bromination. Furthermore, the brominated molecules are more likely to produce inelastic scattering low energy electrons upon exposure to 2000 or 3000 eV X-rays. This modification of electronic properties around the brominated group may both facilitate electron transfer to the brominated site in DNA and increase the probability of reaction with low energy electrons. These processes can induce DNA damage, presumably resulting in debromination of the uracil moiety and a subsequent cytotoxic effect. |
| 書誌情報 |
Physical Chemistry Chemical Physics
巻 25,
号 21,
p. 14836-14847,
発行日 2023-05
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| 出版者 |
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出版者 |
Royal Society of Chemistry |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1463-9084 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1039/D3CP01597A Article type Paper |
