| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-06-12 |
| タイトル |
|
|
タイトル |
Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Keiji Suzuki
Tatsuhiko Imaoka
Masanori Tomita
Megumi Sasatani
Kazutaka Doi
Satoshi Tanaka
Michiaki Kai
Yutaka Yamada
Shizuko Kakinuma
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
While epidemiological data are available for the dose and dose-rate effectiveness factor (DDREF) for human populations, animal models have contributed significantly to providing quantitative data with mechanistic insights. The aim of the current review is to compile both the in vitro experiments with reference to the dose-rate effects of DNA damage and repair, and the animal studies, specific to rodents, with reference to the dose-rate effects of cancer development. In particular, the review focuses especially on the results pertaining to underlying biological mechanisms and discusses their possible involvement in the process of radiation-induced carcinogenesis. Because the concept of adverse outcome pathway (AOP) together with the key events has been considered as a clue to estimate radiation risks at low doses and low dose-rates, the review scrutinized the dose-rate dependency of the key events related to carcinogenesis, which enables us to unify the underlying critical mechanisms to establish a connection between animal experimental studies with human epidemiological studies. |
| 書誌情報 |
Journal of radiation research
巻 64,
号 2,
p. 210-227,
発行日 2023-02
|
| 出版者 |
|
|
出版者 |
Oxford University Press |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-9157 |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
36773323 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1093/jrr/rrad002 |
