| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-01-25 |
| タイトル |
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タイトル |
Environmental enrichment increases radiation-induced apoptosis not spontaneous apotosis in mouse intestinal crypt cells |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yokomizo Shinya
Nishimura Mayumi
Morioka Takamitsu
Enzaka Utako
Tsuruoka Chizuru
Shang Yi
Nishimura Yukiko
Inoue Kazumasa
Fukushi Masahiro
Imaoka Tatsuhiko
Kakinuma Shizuko
Shimada Yoshiya
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background/aim: An enriched environment (EE) modifies apoptotic cell death and promotes cell proliferation in the central nervous system (CNS) in mice. However, few studies have examined the effects of an EE on apoptosis in non-CNS organs in model orgamisms. In addition, the intestinal tract is one of organs at high-risk of carcinogenesis after radiation exposure. Herein we evaluated the effects of an EE on spontaneous and radiation-induced apoptosis in intestinal crypt cells of mice.
Materials and methods: Juvenile (3-week-old) and adult (11-week-old) male B6C3F1 mice were housed in a standard environment or EE for 8 weeks and then were whole-body irradiated with 2 Gy X-rays. Apoptosis in the small intestine and colon was analyzed with antibody against cleaved caspase 3.
Results: The EE significantly reduced body weight; adipose tissue weight; and serum levels of total cholesterol, triglyceride, leptin, and insulin. Although EE did not change the spontaneous apoptotic index without irradiation, it significantly increased the index after irradiation in the colonic crypt. The apoptotic index in the small intestinal crypt showed similar patterns.
Conclusion: An EE enhances radiation-induced apoptosis of stem/progenitor cells in the small intestine and colon without affecting spontaneous apoptosis. An EE may thus reduce the risk of cancer in the intestinal tract after radiation exposure such as radiotherapy. |
| 書誌情報 |
in vivo
巻 6,
号 2,
p. 618-627,
発行日 2022-03
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| 出版者 |
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出版者 |
Stanford University Highwire Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0258-851X |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.21873/invivo.12745 |
