量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Polyphenols are abundant in vegetables and fruit. They have been shown to have various antitumor, antioxidant, and anti-inflammatory effects. Here, we extracted the lipid-soluble fraction of polyphenols from fermented sweet potato ( Ipomoea batatas) . These lipid-soluble polyphenols (PPL) mainly contained caffeic acid derivatives with strong antioxidant ability, which we hypothesized to affect diseases for which oxidative stress is a factor, such as cancer. We therefore investigated the antitumor and chemosensitizing effects of PPL on E0771 murine breast cancer cells. The PPL accumulated in the cells’ cytoplasm due to its high lipophilicity, and reduced reactive oxygen species through its strong antioxidant activity. The PPL also arrested the cell cycle at G 0 /G 1 by suppressing Akt activity, and enhanced the cytotoxicity of anticancer agents. In this model, PPL inhibited tumor growth and enhanced the efficacy of chemotherapy drugs. These results suggest the potential of PPL as a functional food to support cancer therapy.
Lipid-soluble polyphenols from sweet potato exert antitumor activity and enhance chemosensitivity in breast cancer
