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Selenium (Se) deficiency causes a malfunction of GSH-Px, and can give oxidative stress due to increasing H{sub}2{/sub}O{sub}2{/sub}. In this study, a Se-deficient (SeD) mouse as an oxidative stress model was prepared for investigating biological effects of radiation.
SeD diet was started from 2 weeks after giving birth on the dams, and weanling mice were fed SeD diet until the experiments. Weekly time course of liver GSH-Px activity of the mouse, 30-day survival rates of the mouse after whole-body 5.6 Gy X-ray irradiation, and daily time courses of redox status in the brain of the mouse after irradiating 8 Gy X-ray or carbon beam was observed.
The liver GSH-Px activities of 4-week-old SeD mouse were almost none, and they kept no-GSH-Px activity through their life. Almost half numbers of healthy mice were survived in 30 days, however, all of SeD mice were died in 15 days after irradiation. X-ray and carbon ion beam irradiations gave different patterns of the time course of brain redox status after irradiation, while difference between healthy and SeD mice groups could not observed.
SeD mice were sensitive to X-ray irradiation on survival basis. However, SeD mice showed similar responses of brain redox status after irradiating X-ray or carbon beam compare to the healthy mice. Detail relation of the redox responses and H{sub}2{/sub}O{sub}2{/sub} levels are still in progress.
会議概要（会議名, 開催地, 会期, 主催者等）
9th Biennial Meeting for the Society for Free Radical Research Asia
Preparation of Selenium-Deficient Mouse Model for Investigating Biological Effects of Ionizing Radiations
