量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Radiation is a useful tool for disease diagnosis and therapy. On the other hand, a risk of subsequent malignant neoplasms several decades after receiving radiation is a serious public concern. In this study, we introduce our current program on the carcinogenic effect of early-life exposure to radiation using mouse and rat models.
We here show that there exist susceptible age windows for radiation carcinogenesis in a tissue dependent manner. Perinatal period is the most susceptible for radiation-induction of both medulloblastomas and renal cell carcinomas. Irradiation at neonatal and infant age efficiently induces intestinal and liver tumors. Mammary cancers develop frequently at around pubertal exposure. Conversely, the incidence of lung cancers rather increases as a function of age-at-exposure. Underlying mechanisms include age dependent changes in the rate of clonal expansion and susceptibility to radiation-induced cell killing of the progenitor cells.
Recent outcome on age and tissue dependence of radiation carcinogenesis in mice and rats
