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Effects on postnatal neurophysiological development in offspring were
studied following exposure of pregnant Wistar rats to accelerated neon-ion
beams with a LET value of about 30 keV/mm at a dose range from 0.1 Gy to
2.0Gy on the 15th day of gestation. The age at which four physiologic
markers appeared and five reflexes were acquired was examined prior to
weaning. Gain in body weight was monitored until the offspring were 3 months
old. Male offspring were evaluated as young adults using two behavioral
tests. The effects of X-rays at 200 kVp measured for the same biological end
points were studied for comparison. Our previous study on carbon-ion beams
with a LET value of about 13 keV/mm was also cited to elucidate a possible
LET-related effect. For most of the endpoints at early age, significant
alteration was even observed in offspring prenatally received 0.1 Gy of
accelerated neon ions, while neither X rays nor carbon-ions under the same
dose resulted in such a significant alteration compared to that from the
sham-irradiated dams. All offspring whose mothers received 2.0 Gy died prior
to weaning. Offspring from dams irradiated with accelerated neon ions
generally showed higher incidences of prenatal death and preweaning
mortality, markedly delayed accomplishment in their physiological markers
and reflexes, and gain in body weight compared to those exposed to X-rays or
carbon ions at doses of 0.1 to 1.5 Gy. Significantly reduced ratios of main
organ weight to body weight at postnatal ages of 30, 60 and 90 days were
also observed within this dose range. The results indicated that irradiation
with neon ions at 0.1 to 1.5 Gy on day 15 of gestation caused permanent
growth alterations in offspring that were dependent on dose. The alterations
include permanent growth retardation, morphological malformations in main
organs, i.e., microcephaly, diminished reflex attainment, delayed appearance
of physiologic markers, and changes in adult behavior. Such exposure to 0.5
to 1.5 Gy of neon ions resulted in growth retardation and behavioral
alterations that persisted throughout the period of study. Accelerated neon
ions generally induced more detrimental effects than carbon ions and X rays,
indicating that prenatal radiation resulted in LET-related detrimental
effects on postnatal development in rats.
会議概要（会議名, 開催地, 会期, 主催者等）
The 36th Scientific Assembly of Assembly of COSPAR
Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats
