量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Development of the cerebellar cortex in the rat prenatal exposed to X-irradiation was studied. Females were exposed to X-ray at a single dose of 2.0 Gy on embyonic day 21. Cerebellar samples from pups were obtained at different postnatal days. Sections from the samples were serially cut off in a sagittal plane, and then incubated with anti-calbindin-D28 K and anti-inositol 1, 4, 5-triphosphate receptor antibody. The settled Purkinje cells were lined up in the monolayer and their dendritic plexus was always oriented perpendicular to the long axis of the lobule in the control rat. However, such Purkinje cells in the posterior lobes of the irradiated rat formed multi-layers, and orientation of their dendritic plexus was disordered. X-irradiation at the end of rat pregnancy might prevent mainly the generation of the Purkinje cell that played important roles for neuronal pathways.
Study on development of the cerebellar cortex in rats exposed to X-irradiation in utero
