量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Abstract
Purpose: The purpose of this study is to determine the risk factors for developing radiation-induced radiation-induced oroantral or oronasal fistula after carbon-ion radiotherapy.
Materials and Methods: Sixty-two patients with oral or sinonasal tumors who were followed up more than 5 years after carbon-ion radiotherapy were included in this study. Carbon-ion radiotherapy was delivered to 57.6 Gy or 64.0 Gy (RBE) /16 fractions. The clinical factors for the radiation-induced oroantral or oronasal fistula were analyzed using multivariate logistic regression model.
Results: The median follow up period was 88.8 months. Twenty-three patients (37%) developed the radiation-induced oroantral or oronasal fistula. Multivariate logistic regression analysis showed that the number of the teeth in the volume receiving more than 50 Gy (RBE) was a significant risk factor (odds ratio 2.782). Of the 62 patients, 46 without maxillary invasion were re-analyzed to clarify the effect of the dose-volume factors of the maxilla. The data of maxillary V10-60 and D1-5 were added to the multivariate logistic regression model. Consequently, the number of the teeth in the volume receiving more than 50 Gy (RBE) was a significant risk factor (odds ratio 2.466).
Conclusions: The presence of the teeth was the strongest predictive factor for developing oroantral or oronasal fistula.
頭頸部腫瘍に対する炭素イオン線治療後の口腔‐鼻副鼻腔瘻の危険因子に関する研究
