量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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The phase I/II clinical study of carbon ion radiotherapy (CIRT) for choroidal melanoma was commenced in Jan. 2001 at the National Institute of Radiological Sciences(NIRS), which was based on the long line of the study of proton radotherapy(PRT) since Oct. 1986. PRT is applied to small to medium sized tumor, and carbon is used to large sized tumor at present.
So far 41 patients received PRT. Skin reactions and visual acuity status after the therapy were acceptable. Seven patients developed glaucoma and une of them received enucleation. Local recurrence was observed in one patient and 5-year local control rate was 97.4%. Five-year survival and eye retention rate were 85.4% and 95%, respectively.
On the other hand, thirty-three patients received CIRT and 24 patients with follow-up period of more than 6 months were analyzed. Skin reactions after CIRT were comparable to those of PRT. Neovascular glaucoma was observed in 7 patients and the incidence of glaucoma was strongly depending on the site and size of the tumor.All patients were alive without any local recurrence,and only one patient developed liver metastasis at 22.3 months after the treatment.
脈絡膜悪性黒色腫−陽子線を含めて−
