WEKO3
アイテム
{"_buckets": {"deposit": "2f818cbe-5cc9-400a-af79-41529e68eee1"}, "_deposit": {"created_by": 1, "id": "86395", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "86395"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00086395", "sets": ["28"]}, "author_link": ["1054100", "1054096", "1054106", "1054094", "1054101", "1054098", "1054093", "1054103", "1054110", "1054104", "1054102", "1054105", "1054097", "1054095", "1054099", "1054112", "1054111", "1054107", "1054108", "1054109"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2022-09-07", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background/Aims: [18F]Fluoroalkyl groups are essential labeling units because they are considered as surrogates for [11C]methyl moieties, and are coupled to the same functional units as the [11C]methyl group. Many [18F]fluoroalkyated PET tracers have been developed. In general, 18F-fluoroalkylation using [18F]fluoroalkyl reagents requires multi-step radiosynthesis procedures and a multi-pot 18F-labeling synthesizer. To overcome these limitations, a straightforward one-pot method for 18F-fluoroethylation without azeotropic drying of [18F]F- was developed [1]. We have used an improved one-pot 18F-fluoroethylaion method to synthesize 18F-fluoroethylated tracers [2]. In this study, we further modified this one-pot method suitable for 18F-fluoromethylation, and simplified the automated radiosynthesis of two [18F]fluoromethylated tracers using this method. Methods: We synthesized [18F]fluoromethyl tosylate in a mixture of 18F- in K222/K2CO3 acetonitrile solution including 2% water, bis(tosyloxy)methane and cesium carbonate. Without purification of [18F]fluoromethyl tosylate, we directly added a labeling precursor to this mixture for the simplified one-pot 18F-fluoromethylation. Using this procedure equipped to a 18F-labeling synthesizer, [18F]FCho (a PET tracer for imaging tumor) and [18F]FMeNER-D2 (a PET tracer for imaging norepinephrine transporter) were automatically synthesized by the reactions of their corresponding labeling precursors with [18F]fluoromethyl tosylate, respectively. Results: Using the simplified one-pot 18F-fluoromethylation procedure in the automated radiosynthesis, we achieved [18F]FCho and [18F]FMeNER-D2 in approximately 10% of radiochemical yield from 18F- at the end of irradiation (EOI). Radiosynthesis times and radiochemical purities of two 18F-labeled tracers were approximately 60 min after EOI and over 95%, respectively. Conclusions: We have successively synthesized [18F]FCho and [18F]FMeNER-D2 using the simplified one-pot 18F-fluoromethylation method, and achieved automation for all radiosynthesis processes using an 18F-labeling synthesizer. The present method provides a shorter synthesis time and automated procedures with one-pot for the 18F-fluoromethylation strategy.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "第13回世界核医学会(13th Congress of the World Federation of Nuclear Medicine and Biology)", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kazunori, Kawamura"}], "nameIdentifiers": [{"nameIdentifier": "1054093", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakana, Mori"}], "nameIdentifiers": [{"nameIdentifier": "1054094", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Fujinaga"}], "nameIdentifiers": [{"nameIdentifier": "1054095", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurihara, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "1054096", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masanao, Ogawa"}], "nameIdentifiers": [{"nameIdentifier": "1054097", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaito, Tsukagoe"}], "nameIdentifiers": [{"nameIdentifier": "1054098", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohkubo, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "1054099", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiroki, Hashimoto"}], "nameIdentifiers": [{"nameIdentifier": "1054100", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nobuki, Nengaki"}], "nameIdentifiers": [{"nameIdentifier": "1054101", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "1054102", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kazunori, Kawamura", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054103", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakana, Mori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054104", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Fujinaga", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054105", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurihara, Yusuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054106", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masanao, Ogawa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054107", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaito, Tsukagoe", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054108", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohkubo, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054109", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiroki, Hashimoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054110", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nobuki, Nengaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054111", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1054112", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate."}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/86395", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-06-28"}, "publish_date": "2022-06-28", "publish_status": "0", "recid": "86395", "relation": {}, "relation_version_is_last": true, "title": ["Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate."], "weko_shared_id": -1}
Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate.
https://repo.qst.go.jp/records/86395
https://repo.qst.go.jp/records/86395cf0c5387-53c8-431c-99ea-6dc493577299
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-06-28 | |||||
タイトル | ||||||
タイトル | Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Kazunori, Kawamura
× Kazunori, Kawamura× Wakana, Mori× Masayuki, Fujinaga× Kurihara, Yusuke× Masanao, Ogawa× Kaito, Tsukagoe× Ohkubo, Takayuki× Hiroki, Hashimoto× Nobuki, Nengaki× Zhang, Ming-Rong× Kazunori, Kawamura× Wakana, Mori× Masayuki, Fujinaga× Kurihara, Yusuke× Masanao, Ogawa× Kaito, Tsukagoe× Ohkubo, Takayuki× Hiroki, Hashimoto× Nobuki, Nengaki× Zhang, Ming-Rong |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aims: [18F]Fluoroalkyl groups are essential labeling units because they are considered as surrogates for [11C]methyl moieties, and are coupled to the same functional units as the [11C]methyl group. Many [18F]fluoroalkyated PET tracers have been developed. In general, 18F-fluoroalkylation using [18F]fluoroalkyl reagents requires multi-step radiosynthesis procedures and a multi-pot 18F-labeling synthesizer. To overcome these limitations, a straightforward one-pot method for 18F-fluoroethylation without azeotropic drying of [18F]F- was developed [1]. We have used an improved one-pot 18F-fluoroethylaion method to synthesize 18F-fluoroethylated tracers [2]. In this study, we further modified this one-pot method suitable for 18F-fluoromethylation, and simplified the automated radiosynthesis of two [18F]fluoromethylated tracers using this method. Methods: We synthesized [18F]fluoromethyl tosylate in a mixture of 18F- in K222/K2CO3 acetonitrile solution including 2% water, bis(tosyloxy)methane and cesium carbonate. Without purification of [18F]fluoromethyl tosylate, we directly added a labeling precursor to this mixture for the simplified one-pot 18F-fluoromethylation. Using this procedure equipped to a 18F-labeling synthesizer, [18F]FCho (a PET tracer for imaging tumor) and [18F]FMeNER-D2 (a PET tracer for imaging norepinephrine transporter) were automatically synthesized by the reactions of their corresponding labeling precursors with [18F]fluoromethyl tosylate, respectively. Results: Using the simplified one-pot 18F-fluoromethylation procedure in the automated radiosynthesis, we achieved [18F]FCho and [18F]FMeNER-D2 in approximately 10% of radiochemical yield from 18F- at the end of irradiation (EOI). Radiosynthesis times and radiochemical purities of two 18F-labeled tracers were approximately 60 min after EOI and over 95%, respectively. Conclusions: We have successively synthesized [18F]FCho and [18F]FMeNER-D2 using the simplified one-pot 18F-fluoromethylation method, and achieved automation for all radiosynthesis processes using an 18F-labeling synthesizer. The present method provides a shorter synthesis time and automated procedures with one-pot for the 18F-fluoromethylation strategy. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第13回世界核医学会(13th Congress of the World Federation of Nuclear Medicine and Biology) | |||||
発表年月日 | ||||||
日付 | 2022-09-07 | |||||
日付タイプ | Issued |