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量子ドットによる透明化保存肝臓内の網羅的移植膵島イメージング技術の構築
https://repo.qst.go.jp/records/85940
https://repo.qst.go.jp/records/859400778ed78-c117-437b-ad1c-df73a257f73b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-04-08 | |||||
| タイトル | ||||||
| タイトル | 量子ドットによる透明化保存肝臓内の網羅的移植膵島イメージング技術の構築 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
湯川, 博
× 湯川, 博× 舟根, 守× 伊藤, 泰平× 剣持, 敬× 馬場, 嘉信× Hiroshi, Yukawa× Yoshinobu, Baba |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In vivo imaging technology can detect and diagnose almost all of transplanted cells remains unestablished. In order to enhance the safety and treatment effect of regenerative medicine,it is necessary to understand where transplanted cells accumulate in the tissue and how the accumulated cells behave in tissues and organs at a cell level. In this study, we challenged the innovative diagnosis of transplanted islet cells in the liver of mice by advanced technologies such as fluorescence imaging using “quantum dots (QDs)” and whole tissue clearing using “clear, unobstructed brain/body imaging cocktails and computational analysis (CUBIC)”. After transplantation of islet cells labeled with QDs800 into the living body of the nude mice through portal vein, it was confirmed that the transplanted islet cells were mainly accumulated in the liver of the mice after 10 min. of transplantation using in vivo imaging system. In addition, we now examine the spatiotemporal distribution of transplanted islet cells at the single cell level by organ clearing and 3D imaging of organs using light sheet fluorescence microscopy. | |||||
| 書誌情報 |
Organ Biology 巻 28, 号 2, p. 136, 発行日 2022-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1340-5152 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.11378/organbio.28.136 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.11378/organbio.28.136 | |||||
