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Dose- and LET-dependent changes in mouse skin contracture up to a year after either single dose or fractionated doses of carbon ion or gamma rays
https://repo.qst.go.jp/records/85757
https://repo.qst.go.jp/records/85757a4ec6deb-2956-4e55-b3c3-81b5cd19df08
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-25 | |||||
| タイトル | ||||||
| タイトル | Dose- and LET-dependent changes in mouse skin contracture up to a year after either single dose or fractionated doses of carbon ion or gamma rays | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koichi, Ando
× Koichi, Ando× Yukari, Yoshida× Ryoichi, Hirayama× Sachiko, Koike× Naruhiro, Matsufuji× Koichi, Ando× Yukari, Yoshida× Ryoichi, Hirayama× Sachiko, Koike× Naruhiro, Matsufuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Time dependence of relative biological effectiveness (RBE) of carbon ions for skin damage was investigated to answer the question of whether the flat distribution of biological doses within a Spread-Out Bragg peak (SOBP) which is designed based on in vitro cell kill could also be flat for in vivo late responding tissue. Two spots of Indian ink intracutaneously injected into the legs of C3H mice were measured by calipers. An equieffective dose to produce 30% skin contraction was calculated from a dose-response curve and used to calculate the RBE of carbon ion beams. We discovered skin contraction progressed after irradiation and then reached a stable/slow progression phase. Equieffective doses decreased with time and the decrease was most prominent for gamma rays and least prominent for 100 keV/μm carbon ions. Survival parameter of alpha but not beta in the linear-quadratic model is closely related to the RBE of carbon ions. Biological doses within the SOBP increased with time but their distribution was still flat up to 1 year after irradiation. The outcomes of skin contraction studies suggest that (i) despite the higher RBE for skin contracture after carbon ions compared to gamma rays, gamma rays can result in a more severe late effect of skin contracture. This is due to the carbon effect saturating at a lower dose than gamma rays, and (ii) the biological dose distribution throughout the SOBP remains approximately the same even one year after exposure. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 63, 号 2, p. 221-229, 発行日 2022-03 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35021226 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rrab123 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://watermark.silverchair.com/rrab123.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtswggLXBgkqhkiG9w0BBwagggLIMIICxAIBADCCAr0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMyu3bQ1SA2TdnJvfeAgEQgIICjk1nhhrFWIwYc15OAROuz8UuKrLPoBNWHTA0CNbB0HKGpCEVITJIYmv6I1JLBB3QrJngYcQMghfJ_ogpawmLr8ztcLkhbC518wXKST-kYjYdZUBjWPHHDy3_VR2qwuMGAnb0rKJStY3Q0YVlNO9r4Sdh_VMQCtxgdiDHuX-Hh3Q7cbSuY9ceJwqrRxUl5nul6ZX2UYgOY6t4uSfPTekax2fAalc0UqGyqwLBECLj35scHfy_Qx5-AwOzkR0NVC5iV2niokbFk8QmHJXPWd5VnqfH1uxTR98FOZcYzL_M0jHAtLOvWSOLoCf89lP5RQ0u8WnOZWmZa3KvcnM2HhaokwgWlhGuhC5TgkdpXAahX4MsmFTRC00hP2r9YAG4SbCw5O8jotV70_LxHYZ-LHsTZo48tzz0xa3w3L3f7ldSZWaPO9w7zB7UFRmor8KMfSSIa6oYLowoh49kplqLaB66whC9xQdyx0pUGcVlxL6Ga8UiCdPLMxBJHKab_DoZ5IjYP8it049J8Gja8Gb3xKHWpJndNg_wtjiuBazgUbHnT2kRNFTXVeHsbTR5S0B3_4WOXXX2pXyhhKo0S6KrAG0ONLYKe9OcVFulUezFOdnRotLnl4bpq-2PfHl8mDVxlpit7Hc1i1RevWVV8oMANrvHm-Dc3ugLGD90TQfukroKkTJzvsZkYvNg0rkopvaCY95TWHgkC7XrVcvienD6a1Aj6PqHh3P2jomSTakInJmOztoeTCFJmgZFgLWszG6cKRLvYkcXiLr-k1zCt8n-3ua60KNDZ85QXxQrz-qL8YgqxaW7gNhqhBEIL0m4j7lgVWKY5oJSbkwC1fX-1p3nhJdZTYE_CsV3H0qQ6-NrRnjgxg | |||||
