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Radiation crosslinked smart peptide nanoparticles: A new platform for tumor imaging
https://repo.qst.go.jp/records/82145
https://repo.qst.go.jp/records/82145a3288d09-b7a8-4690-8f1b-4b5bb10b1835
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-10 | |||||
| タイトル | ||||||
| タイトル | Radiation crosslinked smart peptide nanoparticles: A new platform for tumor imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
木村, 敦
× 木村, 敦× 上野, 美穂× 新井, 唯史× 大山, 廣太郎× 田口, 光正× Atsushi, Kimura× Miho, Ueno× Tadashi, Arai× Kotaro, Oyama× Mitsumasa, Taguchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nanoparticles have been employed to develop nanosensors and drug carriers that accumulate in tumors. Thus, it is necessary to control the particle size, surface potential, and biodegradability of these nanoparticles for effective tumor accumulation and safe medical application. In this study, to form a nanoparticle platform suitable for diagnostic and drug delivery system (DDS) applications. Peptides composed of aromatic amino acid residues were designed and synthesized based on the radiation crosslinking mechanism of proteins. The peptide nanoparticles, which were produced by -ray irradiation, displayed a positive surface potential, maintained biodegradability, and were stable in water and phosphoric buffer solution during actual diagnosis. The surface potential of the peptide nanoparticles could be changed to negative by using a fluorescent labeling reagent, so that the fluorescent-labeled peptide nanoparticles were uptaken by HeLa cells. The radia-tion-crosslinked nanoparticles can be applied as a platform for tumor-targeting diagnostics and DDS therapy. | |||||
| 書誌情報 |
Nanomaterials 巻 11, 号 3, p. 714, 発行日 2021-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2079-4991 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/nano11030714 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2079-4991/11/3/714 | |||||
