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Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 ApcMin/+ Mice
https://repo.qst.go.jp/records/82060
https://repo.qst.go.jp/records/82060c79587ac-774a-43c7-bd35-8ec5ed221ba5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-04 | |||||
| タイトル | ||||||
| タイトル | Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 ApcMin/+ Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takamitsu, Morioka
× Takamitsu, Morioka× Shunsuke, Yamazaki× Hiromi, Yanagihara× Masaaki, Sunaoshi× Mutsumi, Kaminishi× Shizuko, Kakinuma× Takamitsu, Morioka× Shunsuke, Yamazaki× Hiromi, Yanagihara× Masaaki, Sunaoshi× Mutsumi, Kaminishi× Shizuko, Kakinuma |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim: Progress in cancer treatment and diagnosis has made second cancer after medical radiation exposure a particular concern among childhood cancer survivors. Calorie restriction (CR) is a broadly effective cancer prevention strategy, although its effects on radiation-induced intestinal tumours are unclear. Here we examined the cancer-preventative efficacy of a CR diet at different starting ages on radiation induction of intestinal tumours in mice. Materials and Methods: Male C3B6F1 ApcMin/+ mice were irradiated with 0 or 2 Gy of X-rays at 2 weeks of age. After an interval of 2, 8 or 18 weeks, mice were fed with a non-CR (95 kcal/week/mouse) or CR (65 kcal/week/mouse) diet. Intestinal tumours were evaluated for number, size distribution and malignancy. Results: CR suppressed the size and progression of both spontaneous and radiation-induced intestinal tumours depending on age at starting of CR. CR diets were effective even administered to adult mice. Conclusion: CR was effective for suppression of tumour progression, which was accelerated by radiation exposure. Use of CR might be a useful cancer-prevention strategy for radiation-induced tumours of the intestinal tract. |
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| 書誌情報 |
Anticancer Research 巻 41, 号 3, p. 1365-1375, 発行日 2021-03 |
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| 出版者 | ||||||
| 出版者 | Anticancer Research | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0250-7005 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21873/anticanres.14894 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://ar.iiarjournals.org/content/41/3/1365 | |||||
