WEKO3
アイテム
{"_buckets": {"deposit": "be991602-bd87-48ef-b9eb-03f4df1928ef"}, "_deposit": {"created_by": 1, "id": "80288", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "80288"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00080288", "sets": ["1"]}, "author_link": ["883024", "883025", "883030", "883027", "883031", "883022", "883026", "883029", "883023", "883028"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-06", "bibliographicIssueDateType": "Issued"}, "bibliographicVolumeNumber": "30", "bibliographic_titles": [{"bibliographic_title": "Photodiagnosis and Photodynamic Therapy"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Introduction/Aim\nPhotodynamic therapy (PDT) involves the use of a tumor-specific photosensitizer and laser irradiation, and is one of the treatment options recommended for early centrally located lung cancers, but not yet for peripheral-type lung cancers. We developed a new laser probe, the composite-type optical fiberscope (COF), which allows accurate laser irradiation of a cancer lesion with simultaneous visualization of the lesion. In this study, we attempted a new endobronchial PDT technique using the new laser probe, and evaluated the effectiveness and feasibility of this novel PDT technique for peripheral lung cancers.\n\nMethods\nThis phase I study was conducted in 7 patients with peripheral lung cancers (primary tumor ≤20 mm in diameter). We performed endobronchial PDT for these patients using the new laser probe and talaporfin sodium as the photosensitizer.\n\nResults\nWe performed PDT for 3 patients with peripheral lung cancer using a laser dose of 50 J/cm2 at 120 mW, and confirmed the feasibility of using this dose. Then, we escalated the laser dose to 100 J/cm2 in 4 additional patients. A total of 7 patients met our inclusion criteria. Evaluation at 2 weeks and 3 months after the PDT revealed no complication such as pneumonia or pneumothorax. At the evaluation conducted 6 months later, we found CR in 3 cases and SD in the remaining 4 cases.\n\nConclusion\nPDT was found to be a feasible and non-invasive treatment modality for early peripheral-type lung cancer. In the future, PDT could become a standard treatment option for peripheral-type lung cancer.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.pdpdt.2020.101698", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.sciencedirect.com/science/article/abs/pii/S157210002030051X#!", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1572-1000", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Usuda, Jitsuo"}], "nameIdentifiers": [{"nameIdentifier": "883022", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "883023", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuchida, Takaaki"}], "nameIdentifiers": [{"nameIdentifier": "883024", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohtani, Keishi"}], "nameIdentifiers": [{"nameIdentifier": "883025", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maehara, Sachio"}], "nameIdentifiers": [{"nameIdentifier": "883026", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda, Norihiko"}], "nameIdentifiers": [{"nameIdentifier": "883027", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohsaki, Yoshinobu"}], "nameIdentifiers": [{"nameIdentifier": "883028", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Takaaki"}], "nameIdentifiers": [{"nameIdentifier": "883029", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oka, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "883030", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oka, Kiyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "883031", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/80288", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-08-04"}, "publish_date": "2020-08-04", "publish_status": "0", "recid": "80288", "relation": {}, "relation_version_is_last": true, "title": ["Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study"], "weko_shared_id": -1}
Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study
https://repo.qst.go.jp/records/80288
https://repo.qst.go.jp/records/80288302e1905-c666-4cf7-a0cd-7a1b88ecdd78
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-08-04 | |||||
タイトル | ||||||
タイトル | Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Usuda, Jitsuo
× Usuda, Jitsuo× Inoue, Tatsuya× Tsuchida, Takaaki× Ohtani, Keishi× Maehara, Sachio× Ikeda, Norihiko× Ohsaki, Yoshinobu× Sasaki, Takaaki× Oka, Kiyoshi× Oka, Kiyoshi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction/Aim Photodynamic therapy (PDT) involves the use of a tumor-specific photosensitizer and laser irradiation, and is one of the treatment options recommended for early centrally located lung cancers, but not yet for peripheral-type lung cancers. We developed a new laser probe, the composite-type optical fiberscope (COF), which allows accurate laser irradiation of a cancer lesion with simultaneous visualization of the lesion. In this study, we attempted a new endobronchial PDT technique using the new laser probe, and evaluated the effectiveness and feasibility of this novel PDT technique for peripheral lung cancers. Methods This phase I study was conducted in 7 patients with peripheral lung cancers (primary tumor ≤20 mm in diameter). We performed endobronchial PDT for these patients using the new laser probe and talaporfin sodium as the photosensitizer. Results We performed PDT for 3 patients with peripheral lung cancer using a laser dose of 50 J/cm2 at 120 mW, and confirmed the feasibility of using this dose. Then, we escalated the laser dose to 100 J/cm2 in 4 additional patients. A total of 7 patients met our inclusion criteria. Evaluation at 2 weeks and 3 months after the PDT revealed no complication such as pneumonia or pneumothorax. At the evaluation conducted 6 months later, we found CR in 3 cases and SD in the remaining 4 cases. Conclusion PDT was found to be a feasible and non-invasive treatment modality for early peripheral-type lung cancer. In the future, PDT could become a standard treatment option for peripheral-type lung cancer. |
|||||
書誌情報 |
Photodiagnosis and Photodynamic Therapy 巻 30, 発行日 2020-06 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1572-1000 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.pdpdt.2020.101698 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/abs/pii/S157210002030051X#! |