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Simultaneous measurements of the molar radioactivity, radiochemical purity and chemical impurity in the [11C]choline injection using radio-HPLC with a corona-charged aerosol detector.
https://repo.qst.go.jp/records/79931
https://repo.qst.go.jp/records/799310f92c0fb-c178-4c7b-aa36-e736401695de
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-24 | |||||
| タイトル | ||||||
| タイトル | Simultaneous measurements of the molar radioactivity, radiochemical purity and chemical impurity in the [11C]choline injection using radio-HPLC with a corona-charged aerosol detector. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hashimoto, Hiroki
× Hashimoto, Hiroki× Furutsuka, Kenji× Kawamura, Kazunori× Ohkubo, Takayuki× Ogawa, Masanao× Kurihara, Yusuke× Nengaki, Nobuki× Ming-Rong, Zhang× Hashimoto, Hiroki× Furutsuka, Kenji× Kawamura, Kazunori× Ohkubo, Takayuki× Ogawa, Masanao× Kurihara, Yusuke× Nengaki, Nobuki× Ming-Rong, Zhang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [11C]choline has a weak UV absorption chromophore, and it is challenging to detect less than 1 μg/mL choline using radio-HPLC-UV. In this study, we established an analytical procedure of [11C]choline using the radio- HPLC coupled with the corona-charged aerosol detector. As a result, we achieved more than 100 GBq/μmol (over 0.1 μg/mL of choline) of molar radioactivity at the end of synthesis, over 95% of radiochemical purity, and more than 0.1 μg/mL of 2-dimethyoaminoethanol as a chemical impurity. | |||||
| 書誌情報 |
Applied Radiation and Isotopes 巻 162, 発行日 2020-04 |
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| 出版者 | ||||||
| 出版者 | ELSEVIER | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8043 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.apradiso.2020.109192 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0969804320303213 | |||||
