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Experimental quantification of the relative biological effectiveness of radioactive heavy ion beams
https://repo.qst.go.jp/records/78080
https://repo.qst.go.jp/records/78080c64f74c6-6a6d-4d33-a117-865c282b8be6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-19 | |||||
| タイトル | ||||||
| タイトル | Experimental quantification of the relative biological effectiveness of radioactive heavy ion beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Chacon, Andrew
× Chacon, Andrew× Mohammadi, Akram× Ahmed, Abdella× Akamatsu, Go× Iwao, Yuma× Takyu, Sodai× Nishikido, Fumihiko× Chartier, L.× L. Tran, T.× James, B.× Prokopovich, D.× R. Franklin, D.× Tashima, Hideaki× Guatelli, S.× Yamaya, Taiga× Rosenfeld, A.× Safavi naeini, Mitra× Chacon, Andrew× Mohammadi, Akram× Ahmed, Abdella× Akamatsu, Go× Iwao, Yuma× Takyu, Sodai× Nishikido, Fumihiko× Tashima, Hideaki× Yamaya, Taiga× Safavi naeini, Mitra |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The use of positron-emitting radioactive isotopes for heavy ion therapy has been proposed as a means to increase the number of annihilation photons available for Positron Emission Tomography (PET)-based quality assurance (QA) imaging. The particle stopping point itself, which highly correlates to point of maximum dose, can be directly obtained from PET images with the use of these isotopes. An important step for clinical realisation of this idea is to evaluate the relative biological effectiveness (RBE) of the positron-emitting radioactive heavy ions and compare them to those of the corresponding stable nuclides. In this study, the RBE at 10% survival of two positron-emitting radioactive beams, 11C and 15O, and their corresponding non-radioactive isotopes 12C and 16O, were experimentally evaluated by measuring microdosimetric lineal energy deposition using a silicon-on-insulator mushroom microdosimeter. It was found that the RBE10 of the radioactive beams were statistically indistinguishable from their respective stable counterparts in each of the the entrance, Bragg peak and tail regions. The microdosimetric dose-mean lineal energy, yD was also evaluated for each ion species, with multiple measurements made along the path of the beam, and post-irradiation PET images were acquired and compared between the radioactive and stable beams, demonstrating the greatly improved signal to noise ratio (SNR) which can be achieved with positron-emitting radioactive ion beams. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2019-11-02 | |||||
| 日付タイプ | Issued | |||||
