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Chemogenetic activation of the amygdala specifically disrupts the representation of socio-emotional information in the macaque ventral visual cortex
https://repo.qst.go.jp/records/78047
https://repo.qst.go.jp/records/780474a9de7ec-88ae-4547-a677-5fefad908fbd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-18 | |||||
| タイトル | ||||||
| タイトル | Chemogenetic activation of the amygdala specifically disrupts the representation of socio-emotional information in the macaque ventral visual cortex | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
宮川, 尚久
× 宮川, 尚久× 永井, 裕司× 堀, 由紀子× 松尾, 健× 鈴木, 隆文× 井上, 謙一× 高田, 昌彦× 須原, 哲也× 川嵜, 圭佑× 南本, 敬史× Miyakawa, Naohisa× Nagai, Yuji× Hori, Yukiko× Suhara, Tetsuya× Minamimoto, Takafumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A classical view of object vision emphasizes the hierarchical feed-forward connections from the lower to higher visual cortical areas, however, the contribution of the feedback projections from subcortical areas, such as amygdala—the brain region responsible for emotion and social processing—has been less attended. Here we investigate the role of amygdala in socio-emotional representation in the ventral visual cortex of macaque monkeys. Two monkeys received injections of an adeno-associated viral vector expressing hM3Dq, an excitatory DREADD (Designer Receptor Exclusively Activated by Designer Drug), into unilateral amygdala. Several weeks after the injection, the monkeys underwent a positron emission tomography (PET) scan with a DREADD-selective ligand, [11C]deschloroclozapine (DCZ), confirming in vivo hM3Dq expression in the amygdala. Electrophysiological recording revealed that a low dose of DCZ administration significantly increased neuronal activity in the hM3Dq-expressing region. Further PET scans with [18F]fluorodeoxyglucose revealed that DCZ administration significantly increased metabolic activity not only in the hM3Dq-expressing site of the amygdala but also in several patchy regions in the ipsilateral temporal cortex, including the anterior inferior temporal cortex and the superior temporal sulcus. This suggests that the amygdala enhances excitability of specific visual cortical sites. To examine the functional effect of amygdala excitation on the neural representation in the ventral visual cortex, one of the monkeys received an open surgery to implant an electrocorticogram electrode covering the ipsilateral temporal cortex. Evoked visual response was recorded while the monkey performed a simple fixation during a sequential presentation of visual stimuli, which had two properties: social (face or non-face) and emotional (neutral or negative). We applied support vector machine algorithm to decoded social and emotional information. We successfully decoded face and facial expression, but not emotion in general. Chemogenetic activation of the amygdala decreased decoding performance of facial expression (p< 0.05, chi-squared test) to chance level. These results suggest that the primate amygdala contribute to representation of socio-emotional information in the ventral visual cortex. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第42回 日本神経科学学会大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-07-26 | |||||
| 日付タイプ | Issued | |||||
