WEKO3
アイテム
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Effects of Carbon-ion Beam and Lapatinib Alone, or in Combination in HER2 Positive Breast Cancer Stem-like Cells
https://repo.qst.go.jp/records/77053
https://repo.qst.go.jp/records/7705326a2b903-5578-433e-a8fc-1369438172bc
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-10-03 | |||||
タイトル | ||||||
タイトル | Effects of Carbon-ion Beam and Lapatinib Alone, or in Combination in HER2 Positive Breast Cancer Stem-like Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Sai, Sei
× Sai, Sei× Suzuki, Masao× Vares, Guillaume× Horimoto, Yoshiya× 林, 光弘× Sai, Sei× Suzuki, Masao× Vares, Guillaume× Horimoto, Yoshiya |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the present study, we attempt to investigate effects of carbon-ion beam alone, or in combination with lapatinib, a dual tyrosine kinase inhibitor, on targeting HER2-positive breast cancer stem-like cells (CSCs). Spheroid formation assays confirmed that ESA+/CD24- cells have CSC properties compared to ESA-/CD24+ cells in HER2-positive breast cancer cells. Carbon-ion beam combined with lapatinib significantly suppressed spheroid formation compared to X-rays combined with lapatinib or carbon ion beam alone. Carbon-ion beam combined with lapatinib greatly enhanced apoptosis and also induced autophagy-related expression of Beclin1 and LC3 compared to carbon-ion beam alone, X-rays alone, or X-rays combined with lapatinib. In addition, a large-sized gammaH2AX foci in CSCs were induced by carbon ion beam combined with lapatinib treatment in CSCs compared to cells receiving X-rays or carbon-ion beam alone. In conclusion, combination of carbon-ion beam irradiation and lapatinib has a high potential to kill HER2-positive breast CSCs, causing severe irreparable DNA damage, enhanced autophagy, and apoptosis. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第78回日本癌学会学術総会 | |||||
発表年月日 | ||||||
日付 | 2019-09-26 | |||||
日付タイプ | Issued |