WEKO3
アイテム
{"_buckets": {"deposit": "8fa3b226-280d-44e3-9238-8e88086f92d1"}, "_deposit": {"created_by": 1, "id": "76482", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "76482"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00076482", "sets": ["1"]}, "author_link": ["909057", "909062", "909053", "909059", "909056", "909060", "909055", "909058", "909061", "909054"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": " 8", "bibliographicPageEnd": "3616", "bibliographicPageStart": "3609", "bibliographicVolumeNumber": " 16", "bibliographic_titles": [{"bibliographic_title": "Molecular Pharmaceutics"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Positron emission tomography (PET) imaging with 18F-labeled α-methyl-substituted amino acids exerts significant influence on differential diagnosis of malignant tumors and tumor-like lesions. We newly designed 18F-labeled α-methyl-phenylalanine (18F-FAMP) regioisomers (2-, 3-, or 4-18F-FAMP) and stereoisomers (L- or D-form), and we evaluated their potential as tumor-imaging agents. In tumor bearing mice, L-2-18F-FAMP exhibited significantly higher tumor accumulation than the D-18F-FAMPs or a clinically relevant tracer, L-3-18F-α-methyl-tyrosine (18F-FAMT) (p \u003c 0.05). Specificity of L-2-18F-FAMP for L-type amino acid transporter-1, a tumor-specific transporter, was validated in the cellular uptake studies. The PET imaging with L-2-18F-FAMP clearly visualized the tumor as early as 1 h after injection, and the high tumor accumulation level was retained for 3 h. These findings suggest that L-2-18F-FAMP constitutes a potential PET tracer for tumor-specific imaging.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ACS Publications"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1021/acs.molpharmaceut.9b00446", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00446", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1543-8384", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "花岡, 宏史 群馬大学大学院医学系研究科"}], "nameIdentifiers": [{"nameIdentifier": "909053", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshima, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "909054", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山口, 藍子 群馬大学大学院医学系研究科"}], "nameIdentifiers": [{"nameIdentifier": "909055", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木, 博元 千葉大学大学院薬学研究院"}], "nameIdentifiers": [{"nameIdentifier": "909056", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishioka, Noriko"}], "nameIdentifiers": [{"nameIdentifier": "909057", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口, 徹也 群馬大学大学院医学系研究科"}], "nameIdentifiers": [{"nameIdentifier": "909058", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "荒野, 泰 千葉大学大学院薬学研究院"}], "nameIdentifiers": [{"nameIdentifier": "909059", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "対馬, 義人 群馬大学大学院医学系研究科"}], "nameIdentifiers": [{"nameIdentifier": "909060", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshima, Yasuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "909061", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishioka, Noriko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "909062", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/76482", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-08-02"}, "publish_date": "2019-08-02", "publish_status": "0", "recid": "76482", "relation": {}, "relation_version_is_last": true, "title": ["Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging"], "weko_shared_id": -1}
Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging
https://repo.qst.go.jp/records/76482
https://repo.qst.go.jp/records/76482ba2632d4-77f4-4795-83a0-adc82214b1e7
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-08-02 | |||||
タイトル | ||||||
タイトル | Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
花岡, 宏史 群馬大学大学院医学系研究科
× 花岡, 宏史 群馬大学大学院医学系研究科× Oshima, Yasuhiro× 山口, 藍子 群馬大学大学院医学系研究科× 鈴木, 博元 千葉大学大学院薬学研究院× Ishioka, Noriko× 樋口, 徹也 群馬大学大学院医学系研究科× 荒野, 泰 千葉大学大学院薬学研究院× 対馬, 義人 群馬大学大学院医学系研究科× Oshima, Yasuhiro× Ishioka, Noriko |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Positron emission tomography (PET) imaging with 18F-labeled α-methyl-substituted amino acids exerts significant influence on differential diagnosis of malignant tumors and tumor-like lesions. We newly designed 18F-labeled α-methyl-phenylalanine (18F-FAMP) regioisomers (2-, 3-, or 4-18F-FAMP) and stereoisomers (L- or D-form), and we evaluated their potential as tumor-imaging agents. In tumor bearing mice, L-2-18F-FAMP exhibited significantly higher tumor accumulation than the D-18F-FAMPs or a clinically relevant tracer, L-3-18F-α-methyl-tyrosine (18F-FAMT) (p < 0.05). Specificity of L-2-18F-FAMP for L-type amino acid transporter-1, a tumor-specific transporter, was validated in the cellular uptake studies. The PET imaging with L-2-18F-FAMP clearly visualized the tumor as early as 1 h after injection, and the high tumor accumulation level was retained for 3 h. These findings suggest that L-2-18F-FAMP constitutes a potential PET tracer for tumor-specific imaging. | |||||
書誌情報 |
Molecular Pharmaceutics 巻 16, 号 8, p. 3609-3616, 発行日 2019-07 |
|||||
出版者 | ||||||
出版者 | ACS Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1543-8384 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1021/acs.molpharmaceut.9b00446 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00446 |