WEKO3
アイテム
Nanodiamonds for bioapplications - specific targeting strategies
https://repo.qst.go.jp/records/75747
https://repo.qst.go.jp/records/7574701817d79-55a0-4344-9800-029ba70a23e5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-29 | |||||
| タイトル | ||||||
| タイトル | Nanodiamonds for bioapplications - specific targeting strategies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Terada, Daiki
× Terada, Daiki× Genjo, Takuya× F. Segawa, Takuya× Igarashi, Ryuji× Shirakawa, Masahiro× Daiki, Terada× Takuya, Genjo× Ryuji, Igarashi× Masahiro, Shirakawa |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Nanodiamonds (NDs) provide a unique multitasking system for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological system remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review: This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions: The surface of a ND is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce a ND into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance: In the biomedical field, surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions. |
|||||
| 書誌情報 |
BBA - General Subjects 巻 1864, 号 2, p. 129354, 発行日 2020-02 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0304-4165 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bbagen.2019.04.019 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0304416519301102 | |||||
