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変異原物質により生じるDNAクラスター損傷の性状解析
https://repo.qst.go.jp/records/73029
https://repo.qst.go.jp/records/7302924630183-b5be-4d6a-aafa-664b1cc4f497
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-11-05 | |||||
タイトル | ||||||
タイトル | 変異原物質により生じるDNAクラスター損傷の性状解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The analysis of the cluster DNA lesion by the envioremental mutagen | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
中野, 敏彰
× 中野, 敏彰× Xu, Xu× 金本, 僚太× 平山, 亮一× 鵜澤, 玲子× 井出, 博× Nakano, Toshiaki× Hirayama, Ryoichi× Uzawa, Akiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | DNA lesions in X-ray-irradiated plasmid DNA were specifically labeled with biotin/avidin and directly observed by atomic force microscopy (AFM). The structural complexity of clustered DNA damage was assessed based on the number of DNA lesions per clustered DNA damage site. X-rays generated isolated damage and clustered damage with a ratio of 5:1. Clustered DNA damage contained two lesions (DSB and Base/Base) or three lesions (DSB+Base). In contrast, the Fenton reagent generated isolated damage exclusively: isolated damage vs. clustered damage = 143:1 |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 日本環境変異原学会 第47回大会に参加 | |||||
発表年月日 | ||||||
日付 | 2018-11-01 | |||||
日付タイプ | Issued |