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Comparative exploration of biomarkers in mice exposed to X-ray or Fe-ion radiation
https://repo.qst.go.jp/records/72327
https://repo.qst.go.jp/records/723278168a001-ade8-45e0-bb12-66d72267b157
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-05-17 | |||||
| タイトル | ||||||
| タイトル | Comparative exploration of biomarkers in mice exposed to X-ray or Fe-ion radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
中島, 徹夫
× 中島, 徹夫× Vares, Guillaume× 二宮, 康晴× 王, 冰× 勝部, 孝則× 田中, 薫× 劉, 翠華× 平川, 博一× 丸山, 耕一× 藤森, 亮× 中島 徹夫× 二宮 康晴× 王 冰× 勝部 孝則× 田中 薫× 劉 翠華× 平川 博一× 丸山 耕一× 藤森 亮 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Biological markers, which indicate radiation effects and are used for predicting late effects in the future, are expected to be identified. The purpose of this study is to explore useful biological markers for evaluating radiation effects. Particularly, low-dose particle radiation may induce bystander effects due to low particle fluence and to compare the changes in molecules after particle irradiation with that after X-rays irradiation might possibly detect particle-radiation specific biomarkers. Metabolic analyses were performed in livers of mice irradiated with X-rays. Dose-dependent or dose-specific alterations were evaluated. In addition to it, investigating differences of biomarkers due to radiation quality, specific alteration in metabolites was compared with that in the case of Fe-ion irradiation. Moreover, we tried to detect inflammatory biomarkers in both X-rays and Fe-ion irradiation. Metabolites in livers of mice (C57BL/6J) were analyzed by capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS) one month after X-ray irradiation. Significantly altered metabolites to the control were selected from the irradiation groups and specific trends were evaluated. One month after irradiation, 4, 8 and 16 metabolites were significantly altered in irradiated groups at doses of 0.1Gy, 0.5Gy and 2Gy, respectively, compared to the levels in the control. Significantly altered metabolites included free amino acids. However, changes in free amino acids after Fe-ion irradiation (0, 0.1 and 2 Gy) were not detected. These will be discussed in the viewpoint of amino acid metabolism and usage as biomarkers for evaluating radiation effects with results of cytokine alteration after irradiation. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PTCOG56 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-05-11 | |||||
| 日付タイプ | Issued | |||||
