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Cell-cell communication mediated bystander effects between carbon-ion irradiated tumor and non-irradiated normal cells
https://repo.qst.go.jp/records/71836
https://repo.qst.go.jp/records/718366281b7a7-a5bf-444e-bbc0-7505d4140e8e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-12 | |||||
| タイトル | ||||||
| タイトル | Cell-cell communication mediated bystander effects between carbon-ion irradiated tumor and non-irradiated normal cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鈴木, 雅雄
× 鈴木, 雅雄× 鈴木, 雅雄× 崔, 星× 鈴木 雅雄× 崔 星 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Communication between tumor and normal cells is one of the important concerns for radiotherapy. We focused on the communication of signaling events from carbon-ion irradiated tumor to non-irradiated normal cells. Human glioblastoma cells (T98G) were irradiated with carbon-ion beams (LET=73keV/µm) scheduled to either a single dose (6Gy) or three-fraction doses (3x2Gy) during three consecutive days. Then normal human fibroblasts were co-cultured with T98G in presence or absence of a gap-junction inhibitor using the transwell permeable support system. The single-dose irradiation in absence of the gap-junction inhibitor resulted in increased micronucleus formation, cell death and gene mutation in the bystander normal cells. On the other hand, the fraction-dose irradiation showed higher micronucleus formation and mutation than the single dose, but the same level of cell death with the control. In case of presence of the inhibitor, no differences were observed in three biological endpoints. There is clear evidence that the irradiated tumor cells enable to induce damage in the neighboring non-irradiated normal cells via the gap-junction mediated bystander effect. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第74回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-10-09 | |||||
| 日付タイプ | Issued | |||||
