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Complex interactions between ionizing radiation and carcinogenic chemicals on rat mammary carcinogenesis
https://repo.qst.go.jp/records/71277
https://repo.qst.go.jp/records/712773a3d15fc-ffb8-42af-8654-033a2e23ecdc
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-07 | |||||
| タイトル | ||||||
| タイトル | Complex interactions between ionizing radiation and carcinogenic chemicals on rat mammary carcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Ishikawa, Kenichi× Yamashita, Satoshi× Ushijima, Toshikazu× Imai, Takashi× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 石川 顕一× 今井 高志× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Mechanisms underlying combined effects of more than one carcinogens have not been well illustrated in experimental carcinogenesis models. Materials and Methods: Female Sprague-Dawley rats at 7 weeks of age were treated with ionizing radiation (IR; 0.2-2 Gy) and/or with 1-methyl-1-nitrosourea (MNU, 20 or 40 mg/kg) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP, 40 mg/kg/day for 10 days) and observed until 50 weeks of age. Results: Carcinoma incidence increased linearly as a function of IR dose in the absence of chemicals. Mathematical analysis suggested an additive increase when IR and chemicals were combined. Hras mutations were characteristic of carcinomas induced by chemicals and were overrepresented in carcinomas induced by the combination of IR and MNU, suggesting their interaction at the initiation level. Comprehensive screening using microarrays failed to identify differences in gene expression among carcinomas induced by different treatments. Conclusion: A complex interaction may underlie the combined effect of IR and carcinogenic chemicals in the experimental model. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第72回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-05 | |||||
| 日付タイプ | Issued | |||||
