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Mitochondrial dysfunction induced by heavy-ion radiation in mouse brain: Does hypoxia play a role?
https://repo.qst.go.jp/records/71255
https://repo.qst.go.jp/records/71255a7a430bf-d430-407a-ac27-f4561ced17c9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-24 | |||||
| タイトル | ||||||
| タイトル | Mitochondrial dysfunction induced by heavy-ion radiation in mouse brain: Does hypoxia play a role? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Zhenhua
× Wang, Zhenhua× Hong, Zhang× Bing, Wang× Tanaka, Kaoru× Zhou, Xin× Liu, Yang× Gan, Lu× Sun, Chao× Ｗａｎｇ Ｚｈｅｎｈｕａ× Ｈｏｎｇ Ｚｈａｎｇ× 王 冰× 田中 薫× Ｚｈｏｕ Ｘｉｎ× Ｌｉｕ Ｙａｎｇ× Ｇａｎ Ｌｕ× Ｓｕｎ Ｃｈａｏ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation induced brain injury (RBI) is the most serious adverse reaction in cranial radiotherapy, which will cause the loss of neurons and cerebral capillary and finally result in the cognitive impairment. As the power house of cells, mitochondria play the essential role in keeping the stabilization of brain energy metabolism. However, the mitochondrial DNA (mtDNA) is a vulnerable target of irradiation, the injury of mtDNA might be the root of RBI. Here we used the mitochondria targeted antioxidant MitoQ to scavenge the intra-mitochondria reactive oxygen species (mtROS) and investigated the effects of mtROS in RBI induced by carbon ions. The long PCR results indicated that MitoQ significantly inhibited the mtDNA injury and downregulated the expression of PARP1 and ganma-H2AX. And the MitoQ pretreatment also improved the brain mitochondrial respiration function. The results indicated that the mtROS played key roles in RBI. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成24年度HIMAC共同利用研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-04-23 | |||||
| 日付タイプ | Issued | |||||
