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中皮腫モデルにおけるZDHHC8の発現抑制による放射線増感効果
https://repo.qst.go.jp/records/70563
https://repo.qst.go.jp/records/7056382fc270a-ae03-44a7-9398-05a62302f48b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-06 | |||||
| タイトル | ||||||
| タイトル | 中皮腫モデルにおけるZDHHC8の発現抑制による放射線増感効果 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
須藤, 仁美
× 須藤, 仁美× 辻, 厚至× 佐賀, 恒夫× 須藤 仁美× 辻 厚至× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mesothelioma is a highly aggressive tumor caused by asbestos exposure. Radiotherapy alone cannot effectively prolong the survival of mesothelioma patients. To improve the therapeutic efficacy, a novel molecular-targeted radiosensitizing agent is needed to enhance radiosensitivity of mesothelioma cells. We previously reported that ZDHHC8 knockdown reduced cell survival and induced imperfect G2/M checkpoint after X-irradiation. In this study, we analyzed the effect of ZDHHC8 knockdown on irradiated mesothelioma cells and assessed the therapeutic efficacy in a mesothelioma mouse model. In mesothelioma cells, ZDHHC8 knockdown significantly reduced cell survival after irradiation, induced the imperfect G2/M checkpoint, and increased the number of cells with micronuclei and apoptosis. In the mouse model, the combined treatment with ZDHHC8 siRNA and irradiation significantly suppressed tumor growth and increased apoptosis, whereas ZDHHC8 siRNA alone did not. These results suggest that ZDHHC8 knockdown enhanced radiation-induced chromosomal instability and cell death through the induction of defective G2/M checkpoint, and has the potential to improve the radiotherapy of mesothelioma. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第70回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-10-05 | |||||
| 日付タイプ | Issued | |||||
