WEKO3
アイテム
{"_buckets": {"deposit": "a3e497dc-d3a4-4935-a24f-22845ab1ae81"}, "_deposit": {"created_by": 1, "id": "70529", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "70529"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00070529", "sets": ["28"]}, "author_link": ["692682", "692667", "692672", "692673", "692671", "692674", "692676", "692677", "692683", "692678", "692668", "692670", "692675", "692679", "692680", "692669", "692681"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2011-09-10", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Introduction: Radiolabeled Cu-diacetyl-bis (N4-methylthiosemicarbazone) (*Cu-ATSM), including 60/62/64Cu-ATSM, is a potential imaging agent of hypoxic tumors for use with PET. We have reported that *Cu-ATSM is trapped in tumor cells under over-reduced states, such as hypoxia. In this study, to evaluate *Cu-ATSM as an indicator of intracellular over-reduced states in disorders with mitochondrial dysfunction, we examined correlation between *Cu-ATSM uptake and levels of biological reductant NADH and NADPH with mtDNA (mitochondria DNA)-less \u0026#61554;0 cells and the parental 143B human osteosarcoma cells and with \u0026#61554;0-cybrids carrying mutated mitochondria from a patient of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) (2SD cells) and that carrying wild-type one (2SA cells).", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "2011 World Molecular Imaging Congress (Wmic)", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yoshii, Yukie"}], "nameIdentifiers": [{"nameIdentifier": "692667", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoneda, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "692668", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikawa, Masamichi"}], "nameIdentifiers": [{"nameIdentifier": "692669", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furukawa, Takako"}], "nameIdentifiers": [{"nameIdentifier": "692670", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyono, Yashushi"}], "nameIdentifiers": [{"nameIdentifier": "692671", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "692672", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshii, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "692673", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oyama, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "692674", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okazawa, Hidehiko"}], "nameIdentifiers": [{"nameIdentifier": "692675", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saga, Tsuneo"}], "nameIdentifiers": [{"nameIdentifier": "692676", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujibayashi, Yasuhisa"}], "nameIdentifiers": [{"nameIdentifier": "692677", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "吉井 幸恵", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "692678", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古川 高子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "692679", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森 啓", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "692680", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "吉井 裕", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "692681", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐賀 恒夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "692682", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤林 康久", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "692683", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less \u0026#61554;0 cells and the cybrids carrying MELAS mtDNA mutation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less \u0026#61554;0 cells and the cybrids carrying MELAS mtDNA mutation"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/70529", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-09-14"}, "publish_date": "2011-09-14", "publish_status": "0", "recid": "70529", "relation": {}, "relation_version_is_last": true, "title": ["Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less \u0026#61554;0 cells and the cybrids carrying MELAS mtDNA mutation"], "weko_shared_id": -1}
Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation
https://repo.qst.go.jp/records/70529
https://repo.qst.go.jp/records/70529e6d5adca-a72e-4f3c-ad0a-9310cf4edf3c
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-09-14 | |||||
タイトル | ||||||
タイトル | Radiolabeled Cu-ATSM as a novel indicator of over-reduced states in mitochondrial disorders: studies with mtDNA-less 0 cells and the cybrids carrying MELAS mtDNA mutation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yoshii, Yukie
× Yoshii, Yukie× Yoneda, Makoto× Ikawa, Masamichi× Furukawa, Takako× Kiyono, Yashushi× Mori, Hiroshi× Yoshii, Hiroshi× Oyama, Nobuyuki× Okazawa, Hidehiko× Saga, Tsuneo× Fujibayashi, Yasuhisa× 吉井 幸恵× 古川 高子× 森 啓× 吉井 裕× 佐賀 恒夫× 藤林 康久 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: Radiolabeled Cu-diacetyl-bis (N4-methylthiosemicarbazone) (*Cu-ATSM), including 60/62/64Cu-ATSM, is a potential imaging agent of hypoxic tumors for use with PET. We have reported that *Cu-ATSM is trapped in tumor cells under over-reduced states, such as hypoxia. In this study, to evaluate *Cu-ATSM as an indicator of intracellular over-reduced states in disorders with mitochondrial dysfunction, we examined correlation between *Cu-ATSM uptake and levels of biological reductant NADH and NADPH with mtDNA (mitochondria DNA)-less 0 cells and the parental 143B human osteosarcoma cells and with 0-cybrids carrying mutated mitochondria from a patient of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) (2SD cells) and that carrying wild-type one (2SA cells). | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2011 World Molecular Imaging Congress (Wmic) | |||||
発表年月日 | ||||||
日付 | 2011-09-10 | |||||
日付タイプ | Issued |