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微小環境による乳がん表現型の正常化においてエピジェネティックに制御される遺伝子の探索
https://repo.qst.go.jp/records/70262
https://repo.qst.go.jp/records/7026295cff765-87bc-43cd-ac49-85c547fe88cf
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2010-09-28 | |||||
タイトル | ||||||
タイトル | 微小環境による乳がん表現型の正常化においてエピジェネティックに制御される遺伝子の探索 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
臺野, 和広
× 臺野, 和広× 今岡, 達彦× 西村, まゆみ× 島田, 義也× 臺野 和広× 今岡 達彦× 西村 まゆみ× 島田 義也 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | There is growing evidence that the stromal microenvironment can either positively or negatively regulate the neoplastic behavior of genetically aberrant cells through epigenetic modifications of gene expression. In this study, rat mammary tumors cells induced by the N-nitroso-N-methylurea were transplanted into the cleared fat pads of hosts, i.e., a normal mammary gland stromal microenvironment to see normalization of tumor cells. Consistent with the report by Maffini et al. (Am. J. Pathol., 167:1405, 2005), phenotypically normal ductal outgrowths were observed at from the injected site of mammary tumor cells at three months after transplantation. Currently, we are screening for epigenetically controlled genes involved in tumor normalization by means of both gene expression and CpG island microarrays. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第69回日本癌学会学術総会 | |||||
発表年月日 | ||||||
日付 | 2010-09-24 | |||||
日付タイプ | Issued |