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Contributions of direct and indirect actions in cell killing by high-LET radiations under hypoxic condition
https://repo.qst.go.jp/records/70113
https://repo.qst.go.jp/records/70113f6a71464-002f-44bd-8660-1147e2150a60
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-05-25 | |||||
| タイトル | ||||||
| タイトル | Contributions of direct and indirect actions in cell killing by high-LET radiations under hypoxic condition | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Matsumoto, Yoshitaka× Noguchi, Miho× Takase, Nobuhiro× Kase, Yuki× Tsuruoka, Chizuru× Matsufuji, Naruhiro× Ito, Atsushi× Ando, Koichi× Okayasu, Ryuichi× Furusawa, Yoshiya× 平山 亮一× 松本 孔貴× 鶴岡 千鶴× 松藤 成弘× 伊藤 敦× 岡安 隆一× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The contribution of indirect action mediated by OH radicals in cell killing can be estimated from the maximum degree of protection by dimethylsulfoxide (DMSO), which suppresses indirect action without affecting direct action. Exponentially growing Chinese hamster ovary cells under hypoxic condition were exposed to high-LET radiations of 15 to 480 keV/micrometer in the presence or absence of DMSO and their survival was determined using a colony formation assay. The contribution of indirect action to cell killing decreased with increasing LET. The contribution was estimated to be 22% at an LET of 480 keV/micrometer. The RBE determined at a survival level of 10% increased with LET, reaching a maximum value of 5.06 at 200 keV/micrometer, and decreased thereafter. When the RBE was estimated separately for direct action (RBED) and indirect action (RBEI); the RBED was greater than RBEI over the ion LET range tested. RBED increased with increasing LET and reached a peak value of 9.10 at 480 keV/micrometer. RBEI also peaked at 90 keV/micrometer, but with a value of 2.61. Thus the direct action of heavy-ion beams gives a remarkably higher RBE for cell killing than indirect action. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PTCOG 49 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-05-22 | |||||
| 日付タイプ | Issued | |||||
