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TRANSCRIPTIONAL REGULATION OF Il9r IN RADIATION-INDUCED MOUSE T-CELL LYMPHOMA CELL LINE
https://repo.qst.go.jp/records/69836
https://repo.qst.go.jp/records/69836dff2dc4e-d3f6-406b-b17b-7706364badd2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-08-11 | |||||
| タイトル | ||||||
| タイトル | TRANSCRIPTIONAL REGULATION OF Il9r IN RADIATION-INDUCED MOUSE T-CELL LYMPHOMA CELL LINE | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Kakinuma, Shizuko× Kobayashi, Yoshiro× Shimada, Yoshiya× 尚 奕× 柿沼 志津子× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interleukin-9 (IL-9) is a multifunctional cytokine secreted from TH2 cell. Besides its role during immune and inflammatory responses, its growth promoting and antiapoptotic activities on multiple transformed cells suggest a potential role in tumorigenesis. We previously reported the over-expression and activation of the receptor of IL-9 (IL-9R) in radiation-induced T-cell leukemia (TL) of mice. However, the transcriptional regulation of murine IL-9R gene (Il9r) is rarely reported in T-lineage cells. In this study we established an Il9r-highly-expressing TL cell line and detected the promoter region located at -410 ~ -487 bp upstream translation start codon. EMSA and ChIP assay suggested that chromatin associated with this region was highly acetylated and that TBP was bound in vivo. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KTCC 2009 International Workshop | |||||
| 発表年月日 | ||||||
| 日付 | 2009-06-04 | |||||
| 日付タイプ | Issued | |||||
