WEKO3
アイテム
Carbon Ion Radiotherapy in a Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer
https://repo.qst.go.jp/records/64580
https://repo.qst.go.jp/records/6458084562144-fd34-4058-92b3-7a3103ba7902
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-05-01 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy in a Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamamoto, Naoyoshi
× Yamamoto, Naoyoshi× Baba, Masayuki× Nakajima, Mio× Yoshikawa, Kyosan× Matsufuji, Naruhiro× Minohara, Shinichi× Tsuji, Hiroshi× Kamada, Tadashi× Tsujii, Hirohiko× 山本 直敬× 馬場 雅行× 中嶋 美緒× 吉川 京燦× 松藤 成弘× 辻 比呂志× 鎌田 正× 辻井 博彦 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | From 1994 to 1999, we conducted a phase I/II clinical trial for patients with stage I non-small cell lung cancer (NSCLC) by using carbon ion beams alone, demonstrating optimal doses of 90.0GyE in 18 fractions over 6 weeks (Protocol #9303) and 72.0GyE in 9 fractions over 3 weeks (Protocol #9701), which achieved a more than 95% local control rate with minimal pulmonary damage. In the present study, the total dose was fixed at 72.0GyE in 9 fractions over 3 weeks (Protocol #9802), and at 52.8GyE for stage IA and 60.0GyE for stage 1B in 4 fractions in 1 week (Protocol #0001). Following this schedule, we conducted a phase II clinical trial for stage I NSCLC from 1999 to 2003. We also conducted a phase I/II single fractionation clinical trial (Protocol #0201) as a dose escalation study. The total dose was initially 28.0GyE in 2003, and it was increased to 50.0GyE in 2011. This article describes the intermediate steps. Most targets were irradiated from four oblique directions. A respiratory-gated irradiation system was used for all sessions. Local control and survival were assessed by the Kaplan-Meier method. For statistical testing, the Log-rank test was used. The local control rate for all patients (#9802 and #0001) was 91.5%, and those for T1 and T2 tumors were 96.3% and 84.7%, respectively. While there was a significant difference (p=0.0156) in the tumor control rates between T1 and T2 tumors, there was no significant difference (P=0.1516) between squamous cell carcinomas and non-squamous cell carcinomas. The 5-year cause-specific survival rate was 67.0% (IA: 84.4, IB: 43.7), and the overall survival was 45.3% (IA: 53.9, 1B: 34.2). No adverse effects greater than grade 2 occurred in the lungs. In a single fractionation trial, the 5-year local control rate for 145 patients was 79.9%, and the control rates for T1 and T2 tumors were 81.4% and 78.2%, respectively. No adverse effects greater than grade 2 occurred in the lungs. Carbon beam radiotherapy, an excellent new modality in terms of high QOL and ADL, was proven to be a valid alternative to surgery for stage I NSCLC, especially for elderly and inoperable patients. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | New Frontiers in Cancer Treatment | |||||
| 発表年月日 | ||||||
| 日付 | 2012-04-27 | |||||
| 日付タイプ | Issued | |||||
