WEKO3
アイテム
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High-LET Heavy-Ion Radiation and Adaptive Response
https://repo.qst.go.jp/records/64442
https://repo.qst.go.jp/records/64442fed4b7db-9519-4607-9fff-fedfe84aded5
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2011-12-01 | |||||
タイトル | ||||||
タイトル | High-LET Heavy-Ion Radiation and Adaptive Response | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Vares, Guillaume
× Vares, Guillaume× Bing, Wang× Tanaka, Kaoru× KAKIMOTO, AYANA× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru× Guillaume Vares× 王 冰× 田中 薫× 柿本 彩七× 笠井 清美× 根井 充 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adaptive response(AR) and bystander effect are two important phenomena involved in biological responses to low doses of ionizing radiation(IR). Furthermore, there is a strong interest in better understanding the biological effects of high-LET radiation. In this study, we assessed in vitro the ability of priming low doses (0.01-0.1 Gy) of X-rays and heavy-ion radiation to induce an AR to a subsequent challenging dose (1-4Gy) of high-LET IR(carbon-ion:20 and 40keV/mum, neon-ion : 150keV/mum) in cultured lymphoblastoid TK6, AHH-1 and NH32 cells. Pre-exposure of p53-competent cells (both with low-dose X-rays and high-LET IR) resulted in decreased mutation frequencies at Hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus and different H2AX phosphorylation kinetics, as compared to cells exposed to challenging radiation alone. This phenominon was independent of radiation-induced apoptosis or cell cycle effects. Taken together, our results suggested the existence of an AR to mutagenic effects of heavy-ion radiation in lymphoblastoid cells and the involvement of double-strand break repair mechanisms. Even though the cell directly hit by heavy-ion beams (even at low doses) are likely to suffer significant damage, our results constitute the first report to date indicating that low doses of high-LET radiation can nevertherless induce protective effects against subsequent high-LET irradiation. Taking inter-individual varianbility into account, these results might have interesting implications for high-LET radiation therapy and space research. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 日本放射線影響学会第54回大会 | |||||
発表年月日 | ||||||
日付 | 2011-11-19 | |||||
日付タイプ | Issued |