WEKO3
アイテム
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Mammary tumorigenesis in ApcMin/+ mice is enhanced by X-irradiation with a characteristic age dependence
https://repo.qst.go.jp/records/61537
https://repo.qst.go.jp/records/615370db66d2a-aea5-406d-b412-940a568e40ef
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2006-06-26 | |||||
タイトル | ||||||
タイトル | Mammary tumorigenesis in ApcMin/+ mice is enhanced by X-irradiation with a characteristic age dependence | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Okamoto, Mieko× Nishimura, Mayumi× Kakinuma, Shizuko× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 柿沼 志津子× 島田 義也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ApcMin/+ (Min) mouse is a genetically predisposed model of both intestinal and mammary tumorigenesis. We investigated age-related changes in the susceptibility of mice (before, during and after puberty) to radiation-induced mammary tumorigenesis using this model. Female Min and wild-type mice having the C57BL/6J background were irradiated with 2 Gy of X-rays at 2, 5, 7 and 10 weeks and sacrificed at 18 weeks of age. Min mice irradiated at 7-10 weeks of age (after puberty) developed mammary tumors with squamous metaplasia, whereas their wild-type littermates did not. Interestingly, irradiation of Min mice at 2-5 weeks (before and during puberty, respectively) did not induce mammary tumors but rather cystic nodules with metaplasia. The mammary tumors exhibited increased nuclear beta-catenin protein and loss of the wild-type Apc allele. Our results show that susceptibility to radiation-induced mammary tumorigenesis increases after puberty in Min mice, suggesting that the tumorigenic effect of ionizing radiation targets the lobular-alveolar progenitor cells, which increase in number with age and are controlled by beta-catenin signaling. \nReference: Imaoka T et al. (2005) Radiat. Res. 165(2):165-173. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The 6th Japan-France Workshop | |||||
発表年月日 | ||||||
日付 | 2006-06-23 | |||||
日付タイプ | Issued |