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糖尿病と脳画像研究 -アルツハイマー病発症機序との関連を考える-
https://repo.qst.go.jp/records/58236
https://repo.qst.go.jp/records/582360c16f310-2b42-423b-b7ac-77592aaf6ca1
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-07 | |||||
| タイトル | ||||||
| タイトル | 糖尿病と脳画像研究 -アルツハイマー病発症機序との関連を考える- | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
平野, 成樹
× 平野, 成樹× 島田, 斉× その他× 平野 成樹× 島田 斉 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Several evidences from longitudinal epidemiological studies have demonstrated that diabetes significantly increases the risk of Alzheimer's disease (AD). The underlying pathophysiologies that link diabetes and development of AD are, recurrent hypoglycemia, antioxidative stress due to hyperglycemia, atherosclerosis and vascular lesions, and abnormal insulin signaling in the brain. Emerging evidences from neuroimaging studies of diabetic patients can shed light on the pathomechanisms linking diabetes with AD. In this review, recent neuroimaging findings for diabetes are described.<br/> Diabetic patients have diffuse cortical atrophy with notable vulnerability in the temporal lobe. Hyperinsulinemia and hypoglycemia increases cerebral blood flow and metabolism, while hyperglycemia decreases. Diabetes may facilitate the onset of AD via vascular lesion, poor vascular responsiveness, and aberrant amyloid metabolisms, probably through atherosclerosis. Studies on the brain of patients with diabetes may provide clues for preventive therapy in AD. | |||||
| 書誌情報 |
Brain and Nerve 巻 64, 号 12, p. 1411-1419, 発行日 2012-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1881-6096 | |||||
