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HPRT欠損突然変異高感度検出系を用いた突然変異スペクトルのLET依存性解明
https://repo.qst.go.jp/records/55214
https://repo.qst.go.jp/records/552144b86f8de-97e7-4049-a04e-97124e866479
Item type | 一般雑誌記事 / Article(1) | |||||
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公開日 | 2003-12-09 | |||||
タイトル | ||||||
タイトル | HPRT欠損突然変異高感度検出系を用いた突然変異スペクトルのLET依存性解明 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
田内, 広
× 田内, 広× 笠井, 清美× 古澤, 佳也× 安藤, 興一× 小松, 賢志× 田内 広× 笠井 清美× 古澤 佳也× 安藤 興一 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A novel hyper - sensitive mutation detection system, which uses hamster fibroblast cells carrying a normal human X-chromosome, has been developed. The system is 100-fold more sensitive than the conventional system using an internal Hprt gene. This suggests that the system appears to be able to detect a wide spectrum of mutations, even mutations affecting the expression of important genes in neighborhood of the Hprt gene. A lower limit of radiation dose for mutation induction with the system was found to be around 0.1 Gy. Using this system, we started to investigate low dose-rate effects of heavy particle beam (carbon 290 MeV/u beam) with different LETs. | |||||
書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 117-118, 発行日 2003-10 |
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出版者 | ||||||
出版者 | 放医研 |