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Exogenous carbon monoxide suppresses adaptive response induced in zebrafish embryos in vivo by microbeam protons
https://repo.qst.go.jp/records/54490
https://repo.qst.go.jp/records/54490da450a94-810b-4e46-a71d-e27ffaeba39b
Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2014-03-06 | |||||
タイトル | ||||||
タイトル | Exogenous carbon monoxide suppresses adaptive response induced in zebrafish embryos in vivo by microbeam protons | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Wing, Yan Choi Viann
× Wing, Yan Choi Viann× Yuen, Ping Ng Candy× Kobayashi, Alisa× Konishi, Teruaki× Oikawa, Masakazu× Han, Cheng Shuk× Kwan, Ngok Yu Peter× 小林 亜利紗× 小西 輝昭× 及川 将一 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dechorionated embryos of the zebrafish, Danio rerio, irradiated at 5 h post-fertilization (hpf) with 30 protons delivered to 10 separate positions each with an energy of 3.4 MeV from the microbeam irradiation facility (Single-Particle Irradiation System to Cell, acronym as SPICE) at the National Institute of Radiological Sciences (NIRS), developed radioadaptive response (RAR) against a subsequent challenging exposure of 2 Gy of X-ray irradiation at 10 hpf, corroborated by reduced apoptotic signals at 25 hpf revealed through terminal dUTP transferase-mediated nick end-labeling assay. \nThe effects of the CO liberator tricarbonylchloro(glycinato)ruthenium (II) (CORM-3) on the induction of RAR were examined by transferring the irradiated embryos to freshly prepared medium with the chemical at different time points after the application of the priming dose. Our results showed that transfer of irradiated embryos into media with CORM-3 at 0, 1, 2 and 3 h after application of priming exposure significantly suppressed RAR, while transfer at 5 h did not suppress RAR. This was attributed to the protection of bystander cells from the released CO, which caused less de novo synthesis of factors and thus less efficient induction of RAR. Once the factors were synthesized, RAR was induced, which would not be further affected by the application of CORM-3 introduced at 5 h after the application of the priming dose. |
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書誌情報 |
Journal of Radiation Research 巻 55, 号 S1, p. i115, 発行日 2014-02 |
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出版者 | ||||||
出版者 | Oxford Journals, Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0449-3060 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | doi: 10.1093/jrr/rrt165 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://jrr.oxfordjournals.org/cgi/content/abstract/rrt165? | |||||
関連名称 | http://jrr.oxfordjournals.org/cgi/content/abstract/rrt165? |