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Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer
https://repo.qst.go.jp/records/54270
https://repo.qst.go.jp/records/54270955f6e66-5dec-4d3c-99a8-cbe5dfc5578a
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-14 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× Shinoto, Makoto× Yasuda, Shigeo× Imada, Hiroshi× Kamada, Tadashi× Tsujii, Hirohiko× Tsuji, Hiroshi× Baba, Masayuki× Mizoe, Junetsu× Yoshikawa, Kyosan× Kandatsu, Susumu× Ochiai, Takenori× 山田 滋× 篠藤 誠× 安田 茂雄× 今田 浩史× 鎌田 正× 辻井 博彦× 辻 比呂志× 馬場 雅行× 溝江 純悦× 吉川 京燦× 神立 進× 落合 武徳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Patients and Methods: We conducted a phase I/II dose escalation study of carbon ion radiotherapy . One hundred patients with 105 sites of locally recurrent cancer receiving carbon ion radiotherapy were analyzed. Forty-eight relapses originated in the presacral region, 28 in the pelvic sidewalls, 16 in the perineal region and 8 in the colorectal anastomosis. The total dose ranged from 67.2 to 73.6 gray equivalent (GyE) and was administered in 16 fixed fractions over 4 weeks (4.2to 4.6 GyE/fraction). Results: None of 75 patients treated with the highest total dose of 73.6 GyE experienced National Cancer Institute-Common Toxicity Criteria grade 3 to 5 acute reactions. The local control rate in patients treated with 73.6 GyE in the present study was 97% at one year and 92% at 3 years. Dose escalation was then halted at this leval. The median survival time in patients treated with 73.6 GyE was 54 months (range, 7 to 65 months), and the 1-and 3-year overall survival rates were 71% at 3 years and 39% at 5 years, respectively. Conclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without unacceptable morbidity. |
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| 書誌情報 |
Proceedings of II NIRS-CNAO Joint Symposium on Hadrontherapy (NIRS Experience) 号 NIRS-M-229, p. 11-18, 発行日 2010-03 |
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| 出版者 | ||||||
| 出版者 | National Institute of Radiological Sciences | |||||
