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Combined Effect of Ionizing Radiation and N-Ethyl-N-Nitrosourea on Mutation Induction and Lymphoma Development
https://repo.qst.go.jp/records/54083
https://repo.qst.go.jp/records/540833b30f25a-17be-44ac-b9e6-75f7dc161ba3
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-12-18 | |||||
| タイトル | ||||||
| タイトル | Combined Effect of Ionizing Radiation and N-Ethyl-N-Nitrosourea on Mutation Induction and Lymphoma Development | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamauchi, Kazumi
× Yamauchi, Kazumi× Kakinuma, Shizuko× Nakata, Akifumi× Imaoka, Tatsuhiko× Takabatake, Takashi× Nishimura, Mayumi× Shimada, Yoshiya× 山内 一己× 柿沼 志津子× 中田 章史× 今岡 達彦× 高畠 貴志× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Carcinogenesis in humans is thought to result from exposure to numerous environmental factors. Little is known, however, about how these different factors work in combination to cause cancer. Mouse thymic lymphoma is a good model for research on radiation and chemical carcinogenesis. We examined here the occurrence of thymic lymphoma and mutation induction following exposure to both X-rays and N-ethyl-N-nitrosourea (ENU) in B6C3F1 mice. Mice were exposed weekly to whole body X-irradiation (0.2 or 1.0 Gy per each exposure) for 4 consecutive weeks, ENU (200 ppm) in the drinking water for 4 weeks, or X-irradiation followed by ENU treatment. The incidence of lymphoma after 0.2 and 1.0 Gy were 0 and 10%, respectively. ENU treatment induced lymphoma in 20% of exposed mice. When ENU was combined with 1.0 Gy, lymphoma incidence increased up to 94%, showing a synergistic effect. In contrast, combination of ENU with 0.2 Gy resulted in a decrease in lymphoma incidence, i.e., an antagonistic effect. Mutation frequency of the reporter transgene gpt after ENU exposure alone increased by 10-fold compared to untreated controls. Combined exposure of ENU with 0.2 Gy X-rays dramatically decreased mutant frequency. In contrast, 1.0 Gy X-rays combined with ENU further enhanced mutant frequency and accelerated clonal expansion of mutated cells. In conclusion, mutagenic and carcinogenic effect of combined exposure of X-rays with ENU is dose dependent. | |||||
| 書誌情報 |
Radiation Health Risk Sciences : Proceedings of the First International Symposium of the Nagasaki University Global COE Program "Global Strategic Center for Radiation Health Risk Control" p. 227-231, 発行日 2008 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 978-4-4318-8658 | |||||
