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Influence of diet and metabolism on hematopoietic stem cells and leukemia development following ionizing radiation exposure
https://repo.qst.go.jp/records/49328
https://repo.qst.go.jp/records/49328175b46c1-7bcd-468d-b1a9-909922204083
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-21 | |||||
| タイトル | ||||||
| タイトル | Influence of diet and metabolism on hematopoietic stem cells and leukemia development following ionizing radiation exposure | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Karabulutoglu, Melis
× Karabulutoglu, Melis× Finnon, Rosemary× Imaoka, Tatsuhiko× A. Friedl, Anna× Badie, Christophe× Imaoka, Tatsuhiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The review aims to discuss the prominence of dietary and metabolic regulators in maintaining HSC function, long-term self-renewal and differentiation. Results: Most adult stem cells are preserved in a quiescent, non-motile state in vivo which acts as a “protective state” for stem cells to reduce endogenous stress provoked by DNA replication and cellular respiration as well as exogenous environmental stress. The dynamic balance between quiescence, self-renewal and differentiation is critical for supporting a functional blood system throughout life of an organism. Stress-conditions, e.g. ionizing radiation exposure can trigger the blood forming hematopoietic stem cells (HSCs) to proliferate and migrate through extramedullary tissues to expand the number of HSCs and increase hematopoiesis. In addition, a wealth of investigation validated that deregulation of this balance plays a critical pathogenic role in various different hematopoietic diseases including the leukemia development. Conclusion: The review summarises the current knowledge on how alterations in dietary and metabolic factors could alter the risk of leukemia development following ionizing radiation exposure by inhibiting or even reversing the leukemic progression. Understanding the influence of diet, metabolism and epigenetics on radiation-induced leukemogenesis may lead to the development of practical interventions to reduce the risk in exposed populations. |
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| 書誌情報 |
International Journal of Radiation Biology 巻 95, 号 4, p. 452-479, 発行日 2018-09 |
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| 出版者 | ||||||
| 出版者 | Taylor and Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553002.2018.1490042 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1490042 | |||||
