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Use of a DNA film on a self-assembled monolayer for investigating the physical process of DNA damage induced by core electron ionization
https://repo.qst.go.jp/records/47728
https://repo.qst.go.jp/records/47728f3fcea47-e043-4a88-b8cd-75e676c7ba47
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-04-20 | |||||
タイトル | ||||||
タイトル | Use of a DNA film on a self-assembled monolayer for investigating the physical process of DNA damage induced by core electron ionization | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
成田あゆみ(物質材料研究機構)
× 成田あゆみ(物質材料研究機構)× 藤井, 健太郎× 馬場, 祐治(日本原子力研究開発機構)× 下山, 巌× 藤井 健太郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose:The processes by which deoxyribonucleic acid (DNA) is damaged by soft X-ray irradiation was investigated using a novel two-layer sample composed of a DNA film and self-assembled monolayer (SAM) prepared on an inorganic surface. Materials and methods:A mercaptopropyltrimethoxysilane (MPTS) SAM was formed on a sapphire surface, then oligonucleotide (OGN) molecules were adsorbed on the MPTS-SAM. The thicknesses and chemical states of the layers were determined by X-ray photoelectron spectroscopy (XPS) and near-edge X-ray fine structure (NEXAFS) around the phosphorus (P) and sulfur (S) K-edges, then the sample was irradiated with synchrotron soft X-rays. The chemical state of the OGN molecules before and after irradiation was examined by NEXAFS around the nitrogen (N) K-edge region. Results: The thickness of the MPTS-OGN layer was approximately 7.7 nm. The S atom of the OGN molecules was located at the bottom of the OGN layer. The peak shape of the N K-edge NEXAFS spectra of the MPTS-OGN layers clearly changed following irradiation. Conclusions:The MPTS-OGN layer formed on the sapphire surface, and the chemical states and the structure of the interface were elucidated using synchrotron soft X-rays. The OGN molecules adsorbed on the MPTS films decomposed upon exposure to soft X-ray irradiation. |
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書誌情報 |
International Journal of Radiation Biology 巻 92, 号 11, p. 733-738, 発行日 2016-11 |
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出版者 | ||||||
出版者 | Taylor & Francis | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0955-3002 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/09553002.2016.1179812 |