WEKO3
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N-[4-[6-\n(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-Nmethyl-\n4-[11C]-methylbenzamide ([11C]ITDM) was\nrecently developed as a positron emission tomography\n(PET) ligand for mGluR1. To devise a method for\nmeasurement of the binding potential (BPND) of\n[11C]ITDM to mGluR1, reference tissue methods aimed at\nreplacing measurement of the arterial input function are desirable. In this study, we evaluated a noninvasive\nquantification method of mGluR1 with [11C]ITDM,\ndemonstrating its accuracy using Huntington disease\nmodel R6/2 mice. The BPND measurements based on the\nLogan reference (Logan Ref) method have closely\napproximated that based on the arterial input method. We\nperformed PET analysis with Logan Ref to assess its\naccuracy in quantifying the decline of mGluR1 expression\nin R6/2 mice. Significant decreases in BPND values in R6/2\nmice were detected in cerebellum, thalamus, striatum,\nand cingulate cortex. 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Noninvasive quantification of metabotropic glutamate receptortype 1 with [11C]ITDM:a small-animal PET study
https://repo.qst.go.jp/records/47322
https://repo.qst.go.jp/records/47322e6c3af4d-121a-4b18-ad0a-209f053946c4
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-11-13 | |||||
タイトル | ||||||
タイトル | Noninvasive quantification of metabotropic glutamate receptortype 1 with [11C]ITDM:a small-animal PET study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yamasaki, Tomoteru
× Yamasaki, Tomoteru× Fujinaga, Masayuki× Yui, Joji× Ikoma, Yoko× Hatori, Akiko× Xie, Lin× Wakizaka, Hidekatsu× Kumata, Katsushi× Nengaki, Nobuki× Kawamura, Kazunori× Zhang, Ming-Rong× 山崎 友照× 藤永 雅之× 由井 譲二× 生駒 洋子× 羽鳥 晶子× 謝 琳× 脇坂 秀克× 熊田 勝志× 念垣 信樹× 河村 和紀× 張 明栄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Because of its role in multiple central nervous system (CNS) pathways, metabotropic glutamate receptor type 1 (mGluR1) is a crucial target in the development of pharmaceuticals for CNS disorders. N-[4-[6- (isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-Nmethyl- 4-[11C]-methylbenzamide ([11C]ITDM) was recently developed as a positron emission tomography (PET) ligand for mGluR1. To devise a method for measurement of the binding potential (BPND) of [11C]ITDM to mGluR1, reference tissue methods aimed at replacing measurement of the arterial input function are desirable. In this study, we evaluated a noninvasive quantification method of mGluR1 with [11C]ITDM, demonstrating its accuracy using Huntington disease model R6/2 mice. The BPND measurements based on the Logan reference (Logan Ref) method have closely approximated that based on the arterial input method. We performed PET analysis with Logan Ref to assess its accuracy in quantifying the decline of mGluR1 expression in R6/2 mice. Significant decreases in BPND values in R6/2 mice were detected in cerebellum, thalamus, striatum, and cingulate cortex. We compared autoradiographs of R6/2 mouse brain sections with immunohistochemical images, and found a close correlation between changes in radioactive signal intensity and degree of mGluR1 expression. In conclusion, [11C]ITDM-PET is a promising tool for in vivo quantification of mGluR1 expression. |
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書誌情報 |
Journal of Cerebral Blood Flow & Metabolism 巻 34, 号 1, p. 1-7, 発行日 2014-01 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0271-678X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | doi: 10.1038/jcbfm.2013.243 |