WEKO3
アイテム
Low-dose total body carbon-ion irradiations induce early transcriptional alteration without late Alzheimer's disease-like pathogenesis and memory impairment in mice.
https://repo.qst.go.jp/records/47313
https://repo.qst.go.jp/records/473131a7f4b61-35da-4669-9146-4f274a258756
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-21 | |||||
| タイトル | ||||||
| タイトル | Low-dose total body carbon-ion irradiations induce early transcriptional alteration without late Alzheimer's disease-like pathogenesis and memory impairment in mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Ji, Bin× Ono, Maiko× Hou, Yagun× Ninomiya, Yasuharu× Maruyama, Kouichi× Izumi-Nakajima, Nakako× Begum, Nasrin× Higuchi, Makoto× Fujimori, Akira× Uehara, Yoshihiko× Nakajima, Tetsuo× Suhara, Tetsuya× Nenoi, Mitsuru× 王 冰× 田中 薫× 季 斌× 小野 麻衣子× 方 雅群× 二宮 康晴× 丸山 耕一× 中島 菜花子× ＢＥＧＵＭ ＮＡＳＲＩＮ× 樋口 真人× 藤森 亮× 中島 徹夫× 須原 哲也× 根井 充 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The cause and risk factors of Alzheimer’s disease (AD) are largely unknown. Studies on possible radiation-induced AD-like pathogenesis and behavioral consequences are important as humans are exposed to ionizing radiation (IR) from various sources. It was reported that total body irradiations (TBI) at 10 cGy of low linear energy transfer (LET) X-rays to mice triggered acute transcriptional alterations in genes associated with cognitive dysfunctions. However, it was unknown if low doses of IR could induce AD-like changes late after exposure. We reported previously that 10 cGy X-rays induced early transcriptional response of several AD-related genes in hippocampi without late AD-like pathogenesis and memory impairment in mice. Here further studies on two low doses (5 cGy or 10 cGy) of high LET carbon-ion irradiations are reported. On expression of 84 AD-related genes in hippocampi, at 4 hours after TBI, 5 cGy induced a significant up-regulation of 3 genes (Abca1, Casp3 and Chat), 10 cGy lead to a marked up-regulation of 1 gene (Chat) and a down-regulation of 3 genes (Apoe, Ctsd and Il1a), while at 1 year after TBI, 1 gene (Il1a) was significantly down-regulated in 10 cGy-irradiated animals. Changes in spatial learning ability and memory, and induction of AD-like pathogenesis were not detected by in vivo brain imaging for amyloid beta peptide accumulation and by immunohistochemical staining of amyloid precursor protein, amyloid beta protein, tau and phosphorylated tau protein. These findings indicate that low doses of carbon-ion irradiations did not cause behavioral impairment and AD-like pathological change in mice. | |||||
| 書誌情報 |
Journal of Neuroscience Research 巻 92, 号 7, p. 915-926, 発行日 2014-05 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-4012 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24936619 | |||||
