WEKO3
アイテム
{"_buckets": {"deposit": "7a375d9f-d86c-43ea-862f-edcf9e784a6d"}, "_deposit": {"created_by": 1, "id": "47267", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "47267"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00047267", "sets": ["1"]}, "author_link": ["472760", "472768", "472767", "472774", "472777", "472762", "472753", "472770", "472764", "472769", "472771", "472761", "472778", "472758", "472772", "472759", "472757", "472755", "472775", "472756", "472763", "472751", "472752", "472765", "472754", "472766", "472773", "472776"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "969", "bibliographicPageStart": "961", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{"bibliographic_title": "Theranostics"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We evaluated the efficacy of 2-[5-(4-[(18)F]fluoroethoxy-2-oxo-1,3-benzoxazol-3(2H)-yl)-N-methyl-N-phenylacetamide] ([(18)F]FEBMP) for positron emission tomography (PET) imaging of translocator protein (18 kDa, TSPO). Dissection was used to determine the distribution of [(18)F]FEBMP in mice, while small-animal PET and metabolite analysis were used for a rat model of focal cerebral ischemia. [(18)F]FEBMP showed high radioactivity uptake in mouse peripheral organs enriched with TSPO, and relatively high initial brain uptake (2.67 ± 0.12% ID/g). PET imaging revealed an increased accumulation of radioactivity in the infarcted striatum, with a maximum ratio of 3.20 ± 0.12, compared to non-injured striatum. Displacement with specific TSPO ligands lowered the accumulation levels in infarcts to those on the contralateral side. This suggests that the increased accumulation reflected TPSO-specific binding of [(18)F]FEBMP in vivo. Using a simplified reference tissue model, the binding potential on the infarcted area was 2.72 ± 0.27. Metabolite analysis in brain tissues showed that 83.2 ± 7.4% and 76.4 ± 2.1% of radioactivity was from intact [(18)F]FEBMP at 30 and 60 min, respectively, and that this ratio was higher than in plasma (8.6 ± 1.9% and 3.9 ± 1.1%, respectively). In vitro autoradiography on postmortem human brains showed that TSPO rs6971 polymorphism did not affect binding sites for [(18)F]FEBMP. These findings suggest that [(18)F]FEBMP is a promising new tool for visualization of neuroinflammation.", "subitem_description_type": "Abstract"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "26155312", "subitem_relation_type_select": "PMID"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1838-7640", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tiwari, Anjani"}], "nameIdentifiers": [{"nameIdentifier": "472751", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ji, Bin"}], "nameIdentifiers": [{"nameIdentifier": "472752", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yui, Joji"}], "nameIdentifiers": [{"nameIdentifier": "472753", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujinaga, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "472754", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki, Tomoteru"}], "nameIdentifiers": [{"nameIdentifier": "472755", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Xie, Lin"}], "nameIdentifiers": [{"nameIdentifier": "472756", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Luo, Rui"}], "nameIdentifiers": [{"nameIdentifier": "472757", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimoda, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "472758", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumata, Katsushi"}], "nameIdentifiers": [{"nameIdentifier": "472759", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding"}], "nameIdentifiers": [{"nameIdentifier": "472760", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatori, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "472761", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Jun"}], "nameIdentifiers": [{"nameIdentifier": "472762", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "472763", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, Feng"}], "nameIdentifiers": [{"nameIdentifier": "472764", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "472765", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ティワリ アンジャニ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472766", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "季 斌", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472767", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "由井 譲二", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472768", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤永 雅之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472769", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山崎 友照", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472770", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "謝 琳", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472771", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "下田 陽子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472772", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "熊田 勝志", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472773", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 一鼎", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472774", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "羽鳥 晶子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472775", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "前田 純", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472776", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口 真人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472777", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472778", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "[(18)F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "[(18)F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/47267", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-23"}, "publish_date": "2015-08-23", "publish_status": "0", "recid": "47267", "relation": {}, "relation_version_is_last": true, "title": ["[(18)F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain."], "weko_shared_id": -1}
[(18)F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain.
https://repo.qst.go.jp/records/47267
https://repo.qst.go.jp/records/4726780ca7ea6-35aa-4813-9c2b-258df3e18a40
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-08-23 | |||||
タイトル | ||||||
タイトル | [(18)F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Tiwari, Anjani
× Tiwari, Anjani× Ji, Bin× Yui, Joji× Fujinaga, Masayuki× Yamasaki, Tomoteru× Xie, Lin× Luo, Rui× Shimoda, Yoko× Kumata, Katsushi× Zhang, Yiding× Hatori, Akiko× Maeda, Jun× Higuchi, Makoto× Wang, Feng× Zhang, Ming-Rong× ティワリ アンジャニ× 季 斌× 由井 譲二× 藤永 雅之× 山崎 友照× 謝 琳× 下田 陽子× 熊田 勝志× 張 一鼎× 羽鳥 晶子× 前田 純× 樋口 真人× 張 明栄 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the efficacy of 2-[5-(4-[(18)F]fluoroethoxy-2-oxo-1,3-benzoxazol-3(2H)-yl)-N-methyl-N-phenylacetamide] ([(18)F]FEBMP) for positron emission tomography (PET) imaging of translocator protein (18 kDa, TSPO). Dissection was used to determine the distribution of [(18)F]FEBMP in mice, while small-animal PET and metabolite analysis were used for a rat model of focal cerebral ischemia. [(18)F]FEBMP showed high radioactivity uptake in mouse peripheral organs enriched with TSPO, and relatively high initial brain uptake (2.67 ± 0.12% ID/g). PET imaging revealed an increased accumulation of radioactivity in the infarcted striatum, with a maximum ratio of 3.20 ± 0.12, compared to non-injured striatum. Displacement with specific TSPO ligands lowered the accumulation levels in infarcts to those on the contralateral side. This suggests that the increased accumulation reflected TPSO-specific binding of [(18)F]FEBMP in vivo. Using a simplified reference tissue model, the binding potential on the infarcted area was 2.72 ± 0.27. Metabolite analysis in brain tissues showed that 83.2 ± 7.4% and 76.4 ± 2.1% of radioactivity was from intact [(18)F]FEBMP at 30 and 60 min, respectively, and that this ratio was higher than in plasma (8.6 ± 1.9% and 3.9 ± 1.1%, respectively). In vitro autoradiography on postmortem human brains showed that TSPO rs6971 polymorphism did not affect binding sites for [(18)F]FEBMP. These findings suggest that [(18)F]FEBMP is a promising new tool for visualization of neuroinflammation. | |||||
書誌情報 |
Theranostics 巻 5, 号 9, p. 961-969, 発行日 2015-05 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1838-7640 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26155312 |