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Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[18F]FMeNER-D2.
https://repo.qst.go.jp/records/47210
https://repo.qst.go.jp/records/47210dd97232f-cbd8-43fb-af4e-39d52ca1d538
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-06 | |||||
| タイトル | ||||||
| タイトル | Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[18F]FMeNER-D2. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takano, Harumasa
× Takano, Harumasa× Arakawa, Ryosuke× Nogami, Tsuyoshi× Suzuki, Masayuki× Nagashima, Tomohisa× Fujiwara, Hironobu× Kimura, Yasuyuki× Kodaka, Fumitoshi× Takahata, Keisuke× Shimada, Hitoshi× Murakami, Yoshitaka× Tateno, Amane× Yamada, Makiko× Ito, Hiroshi× Kawamura, Kazunori× Zhang, Ming-Rong× Takahashi, Hidehiko× Kato, Motoichiro× Okubo, Yoshiro× Suhara, Tetsuya× 高野 晴成× 荒川 亮介× 野上 毅× 鈴木 雅之× 永嶌 朋久× 藤原 広臨× 木村 泰之× 小高 文聰× 高畑 圭輔× 島田 斉× 村上 義孝× 舘野 周× 山田 真希子× 伊藤 浩× 河村 和紀× 張 明栄× 高橋 英彦× 加藤 元一郎× 大久保 善朗× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Norepinephrine transporter (NET) plays important roles in the treatment of various neuropsychiatric disorders, such as depression and attention deficit hyperactivity disorder (ADHD). Nortriptyline is a NET-selective tricyclic antidepressant (TCAs) that has been widely used for the treatment of depression. Previous positron emission tomography (PET) studies have reported over 80% serotonin transporter occupancy with clinical doses of selective serotonin reuptake inhibitors (SSRIs), but there has been no report of NET occupancy in patients treated with relatively NET-selective antidepressants. In the present study, we used PET and (S,S)-[18F]FMeNER-D2 to investigate NET occupancies in the thalamus in 10 patients with major depressive disorder taking various doses of nortriptyline, who were considered to be responders to the treatment. Reference data for the calculation of occupancy were derived from age-matched healthy controls. The result showed approximately 50-70% NET occupancies in the brain as a result of the administration of 75-200 mg/d of nortriptyline. The estimated effective dose (ED50) and concentration (EC50) required to induce 50% occupancy was 65.9 mg/d and 79.8 ng/ml, respectively. Furthermore, as the minimum therapeutic level of plasma nortriptyline for the treatment of depression has been reported to be 70 ng/ml, our data indicate that this plasma nortriptyline concentration corresponds to approximately 50% NET occupancy measured with PET, suggesting that more than 50% of central NET occupancy would be appropriate for the nortriptyline treatment of patients with depression. | |||||
| 書誌情報 |
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 巻 17, 号 4, p. 553-560, 発行日 2013-12 |
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| 出版者 | ||||||
| 出版者 | Cambridge, [England] : Cambridge University Press, | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1461-1457 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24345533 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1017/S1461145713001521 | |||||
