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Monte Carlo simulation of small OpenPET prototype with 11C beam irradiation: effects of secondary particles on in-beam imaging
https://repo.qst.go.jp/records/47121
https://repo.qst.go.jp/records/471218fe9d067-e67b-4ada-9d5a-dfcd32646276
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-28 | |||||
| タイトル | ||||||
| タイトル | Monte Carlo simulation of small OpenPET prototype with 11C beam irradiation: effects of secondary particles on in-beam imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirano, Yoshiyuki
× Hirano, Yoshiyuki× Yoshida, Eiji× Kinouchi, Shoko× Nishikido, Fumihiko× Inadama, Naoko× Murayama, Hideo× Yamaya, Taiga× 平野 祥之× 吉田 英治× 木内 尚子× 錦戸 文彦× 稲玉 直子× 村山 秀雄× 山谷 泰賀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In-beam positron emission tomography (PET) can enable visualization of an irradiated field using positron emitters (β+ decay). In particle therapies, many kinds of secondary particles are produced by nuclear interactions, which affect PET imaging. Our purpose in this work was to evaluate effects of secondary particles on in-beam PET imaging using the Monte Carlo simulation code, Geant4, by reproducing an experiment with a small OpenPET prototype in which a PMMA phantom was irradiated by a 11C beam. The number of incident particles to the detectors and their spectra, background coincidence for the PET scan, and reconstructed images were evaluated for three periods, spill-time (beam irradiation), pause-time (accelerating the particles) and beamoff time (duration after the final spill). For spill-time, we tested a background reduction technique in which coincidence events correlated with the accelerator radiofrequency were discarded (RF gated) that has been proposed in the literature. Also, background generation processes were identified. For spilltime, most background coincidences were caused by prompt gamma rays, and only 1.4% of the total coincidences generated β+ signals. Differently, for pause-time and beam-off time, more than 75% of the total coincidence events were signals. Using these coincidence events, we failed to reconstruct images during the spill-time, but we obtained successful reconstructions for the pausetime and beam-off time, which was consistent with the experimental results. From the simulation, we found that the absence of materials in the beam line and using the RF gated technique improved the signal-to-noise ratio for the spill-time. From an additional simulation with range shifter-less irradiation and the RF gated technique, we showed the feasibility of image reconstruction during the spill-time. |
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| 書誌情報 |
Physics in medicine and biology 巻 59, 号 7, p. 1623-1640, 発行日 2014-03 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00319155 | |||||
