WEKO3
アイテム
{"_buckets": {"deposit": "c54c790d-6cdd-474c-b3c4-0f19ba2c91c8"}, "_deposit": {"created_by": 1, "id": "46538", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46538"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046538", "sets": ["1"]}, "author_link": ["463814", "463816", "463817", "463811", "463815", "463818", "463813", "463812", "463810", "463819"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "3634", "bibliographicPageStart": "3625", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "Sensors (Online Only URL:http://www.mdpi.org/sensors/)"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The study aimed to clarify the role of electric pulses in combination with\nchemotherapy on the viability of keratinocyte cell line HaCaT, in the context of its\napplication as a new therapeutic approach for psoriasis. The data show that electroporation\nof HaCaT cells in combination with rifampicin induces cytoskeleton disruption and\nincreases permeability of cell monolayer due to cell-cell junctions interruption, visualized\nby fluorescent imaging of E-cadherin and actin integrity. This was accompanied with\nsynergistic reduction of cell viability. The study proposes a new opportunity for more effective\nskin treatment than chemotherapy. The future application of this electrochemotherapeutic\napproach for combined local treatment of psoriasis may have serous benefits because of a\nhigh possibility to avoid side-effects of conventional chemotherapy.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1424-8220", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nikolova, Biliana"}], "nameIdentifiers": [{"nameIdentifier": "463810", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhelev, Zhivko"}], "nameIdentifiers": [{"nameIdentifier": "463811", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bakalova-Zheleva, Rumiana"}], "nameIdentifiers": [{"nameIdentifier": "463812", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Ichio"}], "nameIdentifiers": [{"nameIdentifier": "463813", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saga, Tsuneo"}], "nameIdentifiers": [{"nameIdentifier": "463814", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "463815", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhelev Zhivko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463816", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "バカロバ ルミアナ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463817", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "青木 伊知男", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463818", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐賀 恒夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463819", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46538", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-04-26"}, "publish_date": "2013-04-26", "publish_status": "0", "recid": "46538", "relation": {}, "relation_version_is_last": true, "title": ["Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis"], "weko_shared_id": -1}
Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis
https://repo.qst.go.jp/records/46538
https://repo.qst.go.jp/records/465387a70b60d-a52c-4990-8040-edac47c6eecb
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-04-26 | |||||
タイトル | ||||||
タイトル | Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Nikolova, Biliana
× Nikolova, Biliana× Zhelev, Zhivko× Bakalova-Zheleva, Rumiana× Aoki, Ichio× Saga, Tsuneo× et.al× Zhelev Zhivko× バカロバ ルミアナ× 青木 伊知男× 佐賀 恒夫 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The study aimed to clarify the role of electric pulses in combination with chemotherapy on the viability of keratinocyte cell line HaCaT, in the context of its application as a new therapeutic approach for psoriasis. The data show that electroporation of HaCaT cells in combination with rifampicin induces cytoskeleton disruption and increases permeability of cell monolayer due to cell-cell junctions interruption, visualized by fluorescent imaging of E-cadherin and actin integrity. This was accompanied with synergistic reduction of cell viability. The study proposes a new opportunity for more effective skin treatment than chemotherapy. The future application of this electrochemotherapeutic approach for combined local treatment of psoriasis may have serous benefits because of a high possibility to avoid side-effects of conventional chemotherapy. |
|||||
書誌情報 |
Sensors (Online Only URL:http://www.mdpi.org/sensors/) 巻 13, 号 3, p. 3625-3634, 発行日 2013-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1424-8220 |