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Hyperfractionated Radiotherapy with Concurrent Docetaxel for Advanced Head and Neck Cancer: A Phase II Study
https://repo.qst.go.jp/records/46511
https://repo.qst.go.jp/records/46511641d4e36-c65e-4662-9f53-d267fea88eb8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-28 | |||||
| タイトル | ||||||
| タイトル | Hyperfractionated Radiotherapy with Concurrent Docetaxel for Advanced Head and Neck Cancer: A Phase II Study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Karasawa, Kumiko
× Karasawa, Kumiko× Matsumoto, Fumihiko× Ito, Shin× Oba, Shinichi× Furuya, Tomohisa× Hirowatari, Hisako× Izawa, Hiromi× Ito, Kana× Sasai, Keisuke× 唐澤 久美子× 笹井 啓資 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: To evaluate the value of hyperfractionated radiotherapy with concurrent use of low-dose docetaxel in locally-advanced head and neck squamous cell cancer (HNSCC). Patients and Methods: Patients eligible for this study had confirmed diagnosis of HNSCC stages II (>10 cm3) to IVB. Radiotherapy was delivered twice daily at 1.2 Gy/fraction to a total dose of 72.0 Gy. Docetaxel (10 mg/m2) was administered weekly during radiotherapy. Results: From March 2003 to October 2008, 70 patients were treated. Primary sites included the oropharynx (n=25), hypopharynx (n=24), larynx (n=18), and other sites (n=3). Major grade 3 acute toxicities included mucositis (n=43) and treatment-related pain (n=20). The median follow-up period for surviving patients was 43 months. The 5-year local control rate and overall survival rate were 62.6% and 61.6%, respectively. Conclusion: This modality is a valuable treatment option for the management of locally-advanced HNSCC. | |||||
| 書誌情報 |
Anticancer Research 巻 32, 号 9, p. 4013-4018, 発行日 2012-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0250-7005 | |||||
